GNG2 and GNB3

Number of citations of the paper that reports this interaction (PMID 22940628)
1

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		GNG2	GNB3
Gene Name		guanine nucleotide binding protein (G protein), gamma 2	guanine nucleotide binding protein (G protein), beta polypeptide 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Plasma Membrane Neuron Projection Cell Body Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity G-protein Beta-subunit Binding	GTPase Activity Signal Transducer Activity Protein Binding Spectrin Binding GTPase Binding
	Biological Process	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of Blood Pressure Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Peptide hormone metabolism Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Incretin synthesis, secretion, and inactivation Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs		Halothane
Diseases
GWAS		Non-melanoma skin cancer ( 23548203)	Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R	11 interactors: GNG10 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 RASD2 TGFBR1
Entrez ID		54331	2784
HPRD ID		16234	00743
Ensembl ID		ENSG00000186469	ENSG00000111664
Uniprot IDs		P59768	E9PCP0 F1T0G5 P16520
PDB IDs		4KFM
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure	Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Synaptic Transmission Response To Organonitrogen Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Cellular Response To Organic Substance Oxidation-reduction Process Response To Organic Substance Cell Surface Receptor Signaling Pathway Small Molecule Metabolic Process Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Protein Kinase B Signaling Cellular Metabolic Process Regulation Of Protein Kinase B Signaling Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Ubiquitination Parathyroid Gland Development Receptor Guanylyl Cyclase Signaling Pathway Locomotory Behavior Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Endothelial Cell Activation Response To Lipid Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Sumoylation Cellular Response To Prostaglandin E Stimulus Synaptic Transmission, Dopaminergic Positive Regulation Of SMAD Protein Import Into Nucleus Activation Of Protein Kinase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of SMAD Protein Import Into Nucleus Regulation Of Signaling
Tagcloud ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	allele alleles black bmi differed excessive fto gained gestational greatest gwg homozygote homozygous income infant m2 modifiable noncarriers nonobese nonrisk obese observational postpartum pounds predisposes pregnant prepregnancy tt weights
Tagcloud (Difference) ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	allele alleles black bmi differed excessive fto gained gestational greatest gwg homozygote homozygous income infant m2 modifiable noncarriers nonobese nonrisk obese observational postpartum pounds predisposes pregnant prepregnancy tt weights
Tagcloud (Intersection) ?