GNB3 and GNG8

Number of citations of the paper that reports this interaction (PubMedID 22940628)
53

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		GNB3	GNG8
Description		G protein subunit beta 3	G protein subunit gamma 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body Extracellular Exosome	Heterotrimeric G-protein Complex Plasma Membrane Membrane
	Molecular Function	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Spectrin Binding GTPase Binding	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Feeding Behavior Regulation Of Cholesterol Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Phospholipid Metabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Social Behavior Nose Development Cellular Response To Pheromone
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Central retinal vein equivalent ( 26567291) High myopia ( 31816047 33830181) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Crohn's disease ( 28067908)
Interacting Genes		11 interacting genes: CIDEB GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNG8 GRK2 RASD2 TGFBR1	1 interacting genes: GNB3
Entrez ID		2784	94235
HPRD ID		00743	13593
Ensembl ID		ENSG00000111664	ENSG00000167414
Uniprot IDs		E9PCP0 F1T0G5 P16520	Q9UK08
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Beta-subunit Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway Synapse Signal Transduction Membrane GTPase Activity Plasma Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Zymogen Binding Cellular Response To Pheromone Edg-2 Lysophosphatidic Acid Receptor Binding PDZ Domain Binding Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Response To Pheromone	Signaling Receptor Complex Adaptor Activity GTPase Binding Cell Volume Homeostasis Regulation Of Triglyceride Metabolic Process Regulation Of Feeding Behavior Regulation Of Phospholipid Metabolic Process Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hormone Metabolic Process Spectrin Binding Heterotrimeric G-protein Complex Regulation Of Cholesterol Metabolic Process Regulation Of Behavior Cell Body Regulation Of Cell Size Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Blood Pressure Regulation Of Cellular Component Size Regulation Of Lipid Metabolic Process GTPase Activity Regulation Of Small Molecule Metabolic Process
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