POLR2B and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		POLR2B	LZTR1
Description		RNA polymerase II subunit B	leucine zipper like post translational regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm RNA Polymerase II, Core Complex Membrane	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Ribonucleoside Binding 5'-3' RNA Polymerase Activity Metal Ion Binding	Protein Binding Small GTPase Binding
	Biological Process	RNA-templated Transcription DNA-templated Transcription Transcription By RNA Polymerase II	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Bitter alcoholic beverage consumption ( 31046077) Congenital heart disease (maternal effect) ( 28468790) Coronary artery disease ( 29212778) Height ( 20881960 25429064) Metabolite levels ( 23823483) White blood cell count ( 29403010)
Interacting Genes		19 interacting genes: BTF3 CALM1 CCNH CDK7 CTDP1 IKBKG ITCH LZTR1 MEN1 OTUD5 POLR2C POLR2D POLR2H POLR2L PTEN RPAP1 SNAR-B2 SUB1 ZSCAN1	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		5431	8216
HPRD ID		15943	08992
Ensembl ID		ENSG00000047315	ENSG00000099949
Uniprot IDs		B4DH29 B4DHJ3 C9J2Y9 P30876	A0A384NL67 Q8N653
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process Nucleus DNA-templated Transcription Transcription By RNA Polymerase II Transcription Factor TFIIK Complex DNA-directed RNA Polymerase Activity CAK-ERCC2 Complex RNA Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm RNA Polymerase II Promoter Clearance Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex DNA-templated Transcription Initiation Transcription Factor TFIIH Holo Complex RNA Polymerase I Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase III Complex Spindle Pole Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein-containing Complex Regulation Of Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Elongation By RNA Polymerase II RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Type I Interferon Production Male Germ Cell Nucleus DNA-templated Transcription Elongation Negative Regulation Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Stabilization CD4-positive, Alpha-beta T Cell Activation RNA Polymerase Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity TFIIF-class Transcription Factor Complex Binding Negative Regulation Of Osteoblast Differentiation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity
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