POLR2B and POLR2H

Number of citations of the paper that reports this interaction (PubMedID 9201987)
0

Data Source:
HPRD (in vitro)

		POLR2B	POLR2H
Description		RNA polymerase II subunit B	RNA polymerase II, I and III subunit H
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm RNA Polymerase II, Core Complex Membrane	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol Protein-DNA Complex
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Ribonucleoside Binding 5'-3' RNA Polymerase Activity Metal Ion Binding	DNA Binding Single-stranded DNA Binding DNA-directed RNA Polymerase Activity
	Biological Process	RNA-templated Transcription DNA-templated Transcription Transcription By RNA Polymerase II	DNA-templated Transcription Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Bitter alcoholic beverage consumption ( 31046077) Congenital heart disease (maternal effect) ( 28468790) Coronary artery disease ( 29212778) Height ( 20881960 25429064) Metabolite levels ( 23823483) White blood cell count ( 29403010)	Diisocyanate-induced asthma ( 25918132) Menopause (age at onset) ( 26414677) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		19 interacting genes: BTF3 CALM1 CCNH CDK7 CTDP1 IKBKG ITCH LZTR1 MEN1 OTUD5 POLR2C POLR2D POLR2H POLR2L PTEN RPAP1 SNAR-B2 SUB1 ZSCAN1	14 interacting genes: BARD1 BRCA1 ERCC6 NFKBIB POLR2A POLR2B POLR2C POLR2D POLR2E POLR2G POLR2I POLR2K POLR2L PTEN
Entrez ID		5431	5437
HPRD ID		15943	09082
Ensembl ID		ENSG00000047315	ENSG00000163882
Uniprot IDs		B4DH29 B4DHJ3 C9J2Y9 P30876	P52434
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4	2F3I 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process Nucleus DNA-templated Transcription Transcription By RNA Polymerase II Transcription Factor TFIIK Complex DNA-directed RNA Polymerase Activity CAK-ERCC2 Complex RNA Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm RNA Polymerase II Promoter Clearance Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex DNA-templated Transcription Initiation Transcription Factor TFIIH Holo Complex RNA Polymerase I Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase III Complex Spindle Pole Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein-containing Complex Regulation Of Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Elongation By RNA Polymerase II RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Type I Interferon Production Male Germ Cell Nucleus DNA-templated Transcription Elongation Negative Regulation Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Stabilization CD4-positive, Alpha-beta T Cell Activation RNA Polymerase Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity TFIIF-class Transcription Factor Complex Binding Negative Regulation Of Osteoblast Differentiation	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity DNA-templated Transcription Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process RNA Polymerase I Complex Macromolecule Metabolic Process Nucleoplasm Nucleus RNA Polymerase III Complex Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex RNA-directed RNA Polymerase Activity RNA-templated Transcription Transcription By RNA Polymerase III BRCA1-B Complex Nucleolus Regulation Of Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase II Promoter Nuclear Ubiquitin Ligase Complex BRCA1-C Complex DNA-templated Transcription Elongation Transcription Elongation By RNA Polymerase I 5'-3' RNA Polymerase Activity BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Negative Regulation Of Cell Cycle Phase Transition DNA-templated Transcription Initiation TRNA Transcription By RNA Polymerase III Transcription-coupled Nucleotide-excision Repair TRNA Transcription DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process RNA Polymerase Binding DNA Binding Translation Initiation Factor Binding Regulation Of DNA Damage Checkpoint Negative Regulation Of Cell Cycle Protein K6-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Dentate Gyrus Development Response To Ionizing Radiation Regulation Of Peptidyl-serine Phosphorylation
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