BRD8 and WEE1

Number of citations of the paper that reports this interaction (PMID 15070733)
128

Data Source:
HPRD (in vivo)

		BRD8	WEE1
Gene Name		bromodomain containing 8	WEE1 G2 checkpoint kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Thyroid Hormone Receptor Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Mitotic Nuclear Division Blood Coagulation Peptidyl-tyrosine Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Regulation Of Cell Cycle
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	G2/M DNA damage checkpoint G2/M Checkpoints G2/M Transition S Phase Cyclin E associated events during G1/S transition Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Mitotic G2-G2/M phases Polo-like kinase mediated events G2/M DNA replication checkpoint
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: FSD2 MIS18A MRGBP PPARG RXRA THRB TRRAP WEE1	21 interactors: BRD8 BRSK1 BRSK2 BTRC CASP3 CDCA3 CDK1 CDK2 CRK CSNK2A1 FBXW11 NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		10902	7465
HPRD ID		04166	01907
Ensembl ID		ENSG00000112983	ENSG00000166483
Uniprot IDs		B4DN43 B5MCW3 F8W820 Q9H0E9	P30291 Q86V29
PDB IDs			1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0
Enriched GO Terms of Interacting Partners?		Peroxisome Proliferator Activated Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Transcription, DNA-templated Cellular Response To Lipid RNA Biosynthetic Process Response To Steroid Hormone Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Response To Retinoic Acid Cellular Response To Vitamin E Positive Regulation Of Translational Initiation By Iron Regulation Of Cholesterol Transporter Activity Mitotic Cell Cycle Process RNA Metabolic Process Chromatin Organization Mitotic Cell Cycle Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Female Receptivity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cellular Macromolecule Biosynthetic Process Placenta Development Negative Regulation Of Collagen Biosynthetic Process Response To Lipid Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hyperoxia Receptor Biosynthetic Process Female Courtship Behavior Negative Regulation Of Multicellular Organismal Metabolic Process Response To Hormone Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Negative Regulation Of Telomerase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter	G2/M Transition Of Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cellular Response To Stimulus Mitotic Cell Cycle Cell Communication Positive Regulation Of Intracellular Transport Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Cellular Protein Catabolic Process Signal Transduction Cellular Macromolecule Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Catabolic Process Cellular Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Apoptotic Process Regulation Of Establishment Of Protein Localization Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Proteolysis Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Tagcloud ?		dispensable heterotrimeric hypothesize ifns ino80 interacted interferons irf9 isg isgs latent nua4 partner pol promoters recruitment remodeling rnai rvb rvb1 rvb2 snf2 srcap stat2 tip60 transactivation unidentified uniquely uri	arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Difference) ?		dispensable heterotrimeric hypothesize ifns ino80 interacted interferons irf9 isg isgs latent nua4 partner pol promoters recruitment remodeling rnai rvb rvb1 rvb2 snf2 srcap stat2 tip60 transactivation unidentified uniquely uri	arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Intersection) ?