BRD8 and TRRAP

Number of citations of the paper that reports this interaction (PMID 12963728)
65

Data Source:
HPRD (in vitro, in vivo)

		BRD8	TRRAP
Gene Name		bromodomain containing 8	transformation/transcription domain-associated protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex	PCAF Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus STAGA Complex Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Thyroid Hormone Receptor Activity	Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Kinase Activity Phosphotransferase Activity, Alcohol Group As Acceptor
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation	DNA Repair Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Phosphorylation Histone Acetylation Histone Deubiquitination Histone H4 Acetylation Histone H2A Acetylation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: FSD2 MIS18A MRGBP PPARG RXRA THRB TRRAP WEE1	16 interactors: ACTL6A ATXN7 BRCA1 BRD8 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MRGBP MYC PYGO2 SKP1 TCF3
Entrez ID		10902	8295
HPRD ID		04166	04310
Ensembl ID		ENSG00000112983	ENSG00000196367
Uniprot IDs		B4DN43 B5MCW3 F8W820 Q9H0E9	Q9Y4A5
PDB IDs
Enriched GO Terms of Interacting Partners?		Peroxisome Proliferator Activated Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Transcription, DNA-templated Cellular Response To Lipid RNA Biosynthetic Process Response To Steroid Hormone Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Response To Retinoic Acid Cellular Response To Vitamin E Positive Regulation Of Translational Initiation By Iron Regulation Of Cholesterol Transporter Activity Mitotic Cell Cycle Process RNA Metabolic Process Chromatin Organization Mitotic Cell Cycle Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Female Receptivity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cellular Macromolecule Biosynthetic Process Placenta Development Negative Regulation Of Collagen Biosynthetic Process Response To Lipid Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hyperoxia Receptor Biosynthetic Process Female Courtship Behavior Negative Regulation Of Multicellular Organismal Metabolic Process Response To Hormone Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Negative Regulation Of Telomerase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter	Chromatin Modification Chromatin Organization Organelle Organization Chromosome Organization Histone H4 Acetylation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Histone Acetylation Macromolecule Biosynthetic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H2A Acetylation Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K4 Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Canonical Wnt Signaling Pathway Regulation Of Fibroblast Proliferation Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Organ Development Cellular Response To Indole-3-methanol Regulation Of Histone Methylation Tissue Development Chromatin Remodeling Regulation Of Chromosome Organization
Tagcloud ?		dispensable heterotrimeric hypothesize ifns ino80 interacted interferons irf9 isg isgs latent nua4 partner pol promoters recruitment remodeling rnai rvb rvb1 rvb2 snf2 srcap stat2 tip60 transactivation unidentified uniquely uri	arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta uncertain validating
Tagcloud (Difference) ?		dispensable heterotrimeric hypothesize ifns ino80 interacted interferons irf9 isg isgs latent nua4 partner pol promoters recruitment remodeling rnai rvb rvb1 rvb2 snf2 stat2 tip60 transactivation unidentified uniquely uri	arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico tgfbeta uncertain validating
Tagcloud (Intersection) ?		srcap