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S1PR5 and GNAO1
Number of citations of the paper that reports this interaction (PubMedID
11069896
)
0
Data Source:
HPRD
(in vitro)
S1PR5
GNAO1
Description
sphingosine-1-phosphate receptor 5
G protein subunit alpha o1
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Membrane
Presynapse
Cytoplasm
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Dendrite
Presynaptic Membrane
Cell Body
Postsynaptic Membrane
Parallel Fiber To Purkinje Cell Synapse
Glutamatergic Synapse
GABA-ergic Synapse
Molecular Function
G Protein-coupled Receptor Activity
Protein Binding
Sphingosine-1-phosphate Receptor Activity
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Adenylate Cyclase Regulator Activity
Hydrolase Activity
Guanyl Nucleotide Binding
G-protein Beta/gamma-subunit Complex Binding
G Protein-coupled Serotonin Receptor Binding
Mu-type Opioid Receptor Binding
Metal Ion Binding
Corticotropin-releasing Hormone Receptor 1 Binding
Biological Process
Sphingosine-1-phosphate Receptor Signaling Pathway
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Vesicle Docking Involved In Exocytosis
Muscle Contraction
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway
G Protein-coupled Dopamine Receptor Signaling Pathway
Locomotory Behavior
Regulation Of Heart Contraction
Negative Regulation Of Insulin Secretion
Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways
G alpha (i) signalling events
Lysosphingolipid and LPA receptors
Ca2+ pathway
Ca2+ pathway
Drugs
Fingolimod
Siponimod
Ozanimod
Diseases
GWAS
LDL cholesterol levels (
32203549
)
Apolipoprotein A1 levels (
32203549
)
Cardioembolic stroke (CCSp classification) (
32047268
)
Chronotype (
30696823
)
Daytime nap (
33568662
)
Diastolic blood pressure (
30578418
)
Dimensional psychopathology (Positive) (
29496196
)
HDL cholesterol levels (
32203549
)
Metabolite levels (
23823483
)
Mitochondrial DNA copy number (
30704525
)
Morning person (
30696823
)
Pulse pressure (
27841878
)
Sleep duration (short sleep) (
30846698
)
Interacting Genes
7 interacting genes:
CCR2
GJA8
GNA12
GNAI1
GNAO1
SMO
SSMEM1
36 interacting genes:
ADORA1
ADRA2A
ADRA2C
APLP2
CACNA1B
CCR5
CRHR1
DCTN2
FFAR2
GABBR1
GNAI1
GPSM2
GRM6
HRH4
KLHL3
NGB
NUCB1
OPRD1
OPRM1
PDE6G
PDE6H
PTPRU
RGS1
RGS10
RGS14
RGS16
RGS19
RGS20
RGS4
RGS5
RGS7
RIC8A
S1PR5
SCN8A
TSHR
ZBTB16
Entrez ID
53637
2775
HPRD ID
05510
00757
Ensembl ID
ENSG00000180739
ENSG00000087258
Uniprot IDs
Q9H228
B3KP89
P09471
Q8N6I9
PDB IDs
7EW1
7YXA
6FUF
6G79
6K41
6OIK
6WWZ
7D76
7D77
7EJ0
7EJ8
7EJA
7EJK
7QVM
7T8X
7T90
7T94
7T96
7W2Z
7W6P
7W7E
7XJJ
7Y24
8DZQ
8E9X
8FN1
8HPT
8HQC
8I95
8I97
8I9L
8I9S
8IA2
8IEC
8IED
8IY9
8IYH
8IYW
8J6D
8JER
8JHN
8JZP
8JZZ
8TZQ
8U02
8XWV
8XX3
8XX6
8XX7
8XXH
8XXR
8XXX
8XXZ
8XYK
8Y0N
8YN7
8YN8
9F33
9F34
Enriched GO Terms of Interacting Partners
?
Guanyl Nucleotide Binding
G-protein Beta/gamma-subunit Complex Binding
Heterotrimeric G-protein Complex
G Protein-coupled Serotonin Receptor Binding
Adenylate Cyclase Regulator Activity
G Protein Activity
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway
Negative Regulation Of Secretion By Cell
G Protein-coupled Serotonin Receptor Signaling Pathway
Negative Regulation Of Secretion
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
T Cell Migration
Homeostasis Of Number Of Cells Within A Tissue
Negative Regulation Of Insulin Secretion
Negative Regulation Of Peptide Secretion
GTPase Activity
Lymphocyte Migration
G Protein-coupled Receptor Binding
GTP Binding
Negative Regulation Of Hormone Secretion
Negative Regulation Of Protein Secretion
Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation
Ventral Midline Determination
Negative Regulation Of Eosinophil Degranulation
Positive Regulation Of Astrocyte Chemotaxis
T-helper 17 Cell Chemotaxis
Chemokine (C-C Motif) Ligand 12 Binding
Chemokine (C-C Motif) Ligand 2 Binding
Chemokine-mediated Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transport
Regulation Of Protein Transport
D5 Dopamine Receptor Binding
Mononuclear Cell Migration
Mu-type Opioid Receptor Binding
Dendrite
Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages
Positive Regulation Of Thymocyte Migration
Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation
Chemokine (C-C Motif) Ligand 7 Binding
Positive Regulation Of Hematopoietic Stem Cell Migration
Regulation Of Astrocyte Chemotaxis
Regulation Of Establishment Of Protein Localization
D2 Dopamine Receptor Binding
Negative Regulation Of Protein Transport
Positive Regulation Of Relaxation Of Smooth Muscle
Regulation Of Secretion By Cell
Contact Inhibition
Pancreas Morphogenesis
G Protein-coupled Receptor Signaling Pathway
G-protein Alpha-subunit Binding
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Activity
Plasma Membrane
Signal Transduction
Regulation Of G Protein-coupled Receptor Signaling Pathway
GTPase Activity
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Secretion By Cell
Regulation Of Signaling
GTPase Activator Activity
Negative Regulation Of Secretion
Negative Regulation Of Epinephrine Secretion
Negative Regulation Of Transport
Negative Regulation Of Hormone Secretion
Negative Regulation Of Protein Secretion
Regulation Of Amine Transport
Regulation Of Hormone Secretion
G Protein-coupled Peptide Receptor Activity
Negative Regulation Of Insulin Secretion
Negative Regulation Of Catecholamine Secretion
Membrane
Regulation Of Secretion By Cell
Negative Regulation Of Peptide Secretion
Negative Regulation Of Amino Acid Transport
GDP-dissociation Inhibitor Activity
Regulation Of Secretion
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Negative Regulation Of Protein Transport
Negative Regulation Of Establishment Of Protein Localization
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Alpha2-adrenergic Receptor Activity
Response To Alcohol
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Regulation Of Biological Quality
Positive Regulation Of GTPase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Signaling
Positive Regulation Of ERBB Signaling Pathway
Dendrite
Regulation Of Signal Transduction
Cell Communication
Regulation Of MAPK Cascade
Regulation Of Peptide Hormone Secretion
Negative Regulation Of Norepinephrine Secretion
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Tagcloud (Intersection)
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