SGK2 and PMM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGK2	PMM2
Description		serum/glucocorticoid regulated kinase 2	phosphomannomutase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Neuronal Cell Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Protein Serine Kinase Activity	Phosphomannomutase Activity Protein Binding Isomerase Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Response To Oxidative Stress Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation	Mannose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Biosynthetic Process From Mannose GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate
Pathways		Stimuli-sensing channels	Defective PMM2 causes PMM2-CDG Synthesis of GDP-mannose
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Daytime sleep phenotypes ( 27126917) Weight ( 34074324)	Glaucoma (high intraocular pressure) ( 25173107)
Interacting Genes		9 interacting genes: APP DAPK1 HIRIP3 IL3RA NEDD4 NEDD4L PDPK1 PMM2 PTOV1	3 interacting genes: ACY3 MEOX2 SGK2
Entrez ID		10110	5373
HPRD ID		06348	03472
Ensembl ID		ENSG00000101049	ENSG00000140650
Uniprot IDs		Q9HBY8	A0A0S2Z4J6 O15305 Q59F02
PDB IDs			2AMY 2Q4R 7O0C 7O1B 7O4G 7O58 7O5Z
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Positive Regulation Of Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Neuromuscular Junction Development Regulation Of Toll-like Receptor Signaling Pathway Receptor Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synapse Organization DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Dendrite Morphogenesis Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process 3-phosphoinositide-dependent Protein Kinase Activity H2A-H2B Histone Complex Chaperone Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Receptor Internalization Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Transport Interleukin-3 Receptor Activity Channel Inhibitor Activity Regulation Of Potassium Ion Transport Phosphomannomutase Activity GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate
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