SGK2 and IL3RA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SGK2	IL3RA
Gene Name		serum/glucocorticoid regulated kinase 2	interleukin 3 receptor, alpha (low affinity)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Cytosol	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity	Interleukin-3 Receptor Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Response To Oxidative Stress Positive Regulation Of Transporter Activity Ion Transmembrane Transport Intracellular Signal Transduction Regulation Of Cell Proliferation Transmembrane Transport	Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Ion channel transport Stimuli-sensing channels	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs			Sargramostim
Diseases
GWAS			Schizophrenia ( 17522711)
Protein-Protein Interactions		5 interactors: APP IL3RA NEDD4 NEDD4L PDPK1	15 interactors: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2
Entrez ID		10110	3563
HPRD ID		06348	02392
Ensembl ID		ENSG00000101049	ENSG00000185291
Uniprot IDs		Q9HBY8	P26951
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Sodium Ion Transport Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Response To Abiotic Stimulus Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Neuromuscular Junction Development Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Osmotic Stress Regulation Of Synapse Structure Or Activity Negative Regulation Of Ion Transport Regulation Of Ion Transport Cellular Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Cell Activation Positive Regulation Of Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Synaptic Growth At Neuromuscular Junction Interleukin-3-mediated Signaling Pathway Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Ion Homeostasis Protein Polyubiquitination Synapse Organization Signal Transduction Collateral Sprouting In Absence Of Injury Response To Organic Substance Platelet Activation Positive Regulation Of Ion Transport Intracellular Receptor Signaling Pathway Regulation Of Cellular Localization Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Cell Communication Negative Regulation Of Signal Transduction Collateral Sprouting	Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of JAK-STAT Cascade Response To Organic Substance Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Positive Regulation Of DNA Replication Regulation Of Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Phosphorylation Cellular Protein Modification Process Response To Lipopolysaccharide Cellular Response To Stimulus Response To Molecule Of Bacterial Origin Response To Stimulus Response To Cytokine Regulation Of Protein Import Into Nucleus, Translocation Regulation Of DNA Replication Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Lipid Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Macrophage Activation Regulation Of Phosphorus Metabolic Process Response To Toxic Substance Regulation Of Protein Metabolic Process Response To Bacterium Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Growth Hormone Histone Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Intracellular Signal Transduction
Tagcloud ?		annotated chance cigarette consumed curated cyps distinguished eagle epidemiologic fdr fresh frozen genetics heme hfe hpx indirectly manually meat meats mthfr ncr1 ontology played slcs tpo u133a ucp3 wnts	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		annotated chance cigarette consumed curated cyps distinguished eagle epidemiologic fdr fresh frozen genetics heme hfe hpx indirectly manually meat meats mthfr ncr1 ontology played slcs tpo u133a ucp3 wnts	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?