OGDH

Description		oxoglutarate dehydrogenase
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors Thiamine Pyrophosphate Binding Heat Shock Protein Binding Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process NAD+ Metabolic Process Cerebellar Cortex Development Striatum Development Hippocampus Development Thalamus Development Pyramidal Neuron Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Olfactory Bulb Mitral Cell Layer Development
Pathways		Glycine degradation Mitochondrial protein degradation OGDH complex synthesizes succinyl-CoA from 2-OG
Drugs		NADH Valproic acid Xanthinol
Diseases		Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer in never smokers ( 28604730) Systolic blood pressure change trajectory ( 27980656)
Novel Interacting Genes		1 novel interacting genes: SERPINB7
Interacting Genes		6 interacting genes: ANXA2 DLD DLST HSD17B10 PLSCR1 USP7
Entrez ID		4967
HPRD ID		08938
Ensembl ID		ENSG00000105953
Uniprot IDs		A0A140VJQ5 B4DH65 B4E3E9 E9PCR7 E9PDF2 Q02218
PDB IDs		3ERY 7WGR 8I0K
Enriched GO Terms of Interacting Partners?		Oxoadipate Dehydrogenase Complex Oxoglutarate Dehydrogenase Complex Succinyl-CoA Metabolic Process Amino Acid Catabolic Process 2-oxoglutarate Metabolic Process Branched-chain Amino Acid Catabolic Process Branched-chain Amino Acid Metabolic Process Acetyl-CoA Metabolic Process Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Aspartate Family Amino Acid Metabolic Process Negative Regulation Of Endocytosis Dihydrolipoyl Dehydrogenase (NADH) Activity 2-oxoglutarate Decarboxylation To Succinyl-CoA Acetyltransferase Complex Dihydrolipoyllysine-residue Succinyltransferase Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process Serine-type Endopeptidase Inhibitor Activity Acyl-CoA Metabolic Process Dicarboxylic Acid Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport AnxA2-p11 Complex PCSK9-AnxA2 Complex Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Succinyl-CoA Biosynthetic Process 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Lead Ion Binding Positive Regulation Of Platelet-derived Growth Factor Production Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport Regulation Of Vesicle-mediated Transport Acrosomal Matrix L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Phosphatidylserine Biosynthetic Process Mercury Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface
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