OGDH and DLD

Number of citations of the paper that reports this interaction (PMID 9727038)
6

Data Source:
HPRD (in vitro)

		OGDH	DLD
Gene Name		oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	dihydrolipoamide dehydrogenase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Cilium Acrosomal Matrix
	Molecular Function	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Thiamine Pyrophosphate Binding Heat Shock Protein Binding Oxoglutarate Dehydrogenase (NAD+) Activity Metal Ion Binding Chaperone Binding	Dihydrolipoyl Dehydrogenase Activity Mercury (II) Reductase Activity Mercury Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process NADH Metabolic Process Cerebellar Cortex Development Striatum Development Hippocampus Development Thalamus Development Pyramidal Neuron Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process Olfactory Bulb Mitral Cell Layer Development	Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Lysine Catabolic Process Gastrulation Branched-chain Amino Acid Catabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Nitrogen Compound Metabolic Process Regulation Of Membrane Potential Cellular Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Sperm Capacitation Detoxification Of Mercury Ion
Pathways		Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Branched-chain amino acid catabolism Signaling by Retinoic Acid Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)
Drugs		NADH Valproic Acid	NADH Nicotinamide-Adenine-Dinucleotide Flavin-Adenine Dinucleotide
Diseases
GWAS			Ulcerative colitis ( 23128233 20228799 19122664)
Protein-Protein Interactions		3 interactors: DLD DLST PLSCR1	3 interactors: OGDH PDHX SLC2A4
Entrez ID		4967	1738
HPRD ID		08938	02006
Ensembl ID		ENSG00000105953	ENSG00000091140
Uniprot IDs		B4E3E9 E9PCR7 E9PDF2 E9PFG7 Q02218	B4DT69 E9PEX6 P09622
PDB IDs		3ERY	1ZMC 1ZMD 1ZY8 2F5Z 3RNM
Enriched GO Terms of Interacting Partners?		Lysine Catabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Cellular Amino Acid Catabolic Process Cellular Respiration Carboxylic Acid Catabolic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Alpha-amino Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Phosphatidylserine Biosynthetic Process Generation Of Precursor Metabolites And Energy Cellular Amino Acid Metabolic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phospholipid Scrambling Detoxification Of Mercury Ion Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Sperm Capacitation Branched-chain Amino Acid Catabolic Process Response To Interferon-beta Acetyl-CoA Metabolic Process Response To Mercury Ion Phosphatidylserine Metabolic Process Positive Regulation Of ATPase Activity Regulation Of Mast Cell Activation Acute-phase Response Regulation Of ATPase Activity Mitochondrial Electron Transport, NADH To Ubiquinone Organophosphate Metabolic Process Carboxylic Acid Metabolic Process Negative Regulation Of Viral Genome Replication Organic Acid Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Acyl-CoA Metabolic Process Regulation Of Membrane Lipid Distribution Regulation Of Viral Genome Replication Oxidative Phosphorylation Negative Regulation Of Viral Process Acute Inflammatory Response Cellular Nitrogen Compound Metabolic Process Regulation Of Fatty Acid Metabolic Process Phospholipid Transport Oxidation-reduction Process Nitrogen Compound Metabolic Process Respiratory Electron Transport Chain Cell Redox Homeostasis Electron Transport Chain	Pyruvate Metabolic Process Amylopectin Biosynthetic Process Olfactory Bulb Mitral Cell Layer Development Succinyl-CoA Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb Small Molecule Metabolic Process Lysine Catabolic Process Glucose Import Pyramidal Neuron Development Pyramidal Neuron Differentiation Monocarboxylic Acid Metabolic Process Thalamus Development 2-oxoglutarate Metabolic Process Striatum Development Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate NADH Metabolic Process Regulation Of Acyl-CoA Biosynthetic Process Subpallium Development Hexose Transmembrane Transport Cellular Response To Osmotic Stress Forebrain Neuron Development Tricarboxylic Acid Cycle Olfactory Bulb Development Citrate Metabolic Process Brown Fat Cell Differentiation Carboxylic Acid Metabolic Process Olfactory Lobe Development Carbohydrate Metabolic Process NAD Metabolic Process Tricarboxylic Acid Metabolic Process Organic Acid Metabolic Process Carbohydrate Transmembrane Transport Aerobic Respiration Forebrain Neuron Differentiation Acyl-CoA Metabolic Process Cerebellar Cortex Development Glucose Transport Hippocampus Development Hexose Transport Forebrain Generation Of Neurons Nicotinamide Nucleotide Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Osmotic Stress Diencephalon Development Dicarboxylic Acid Metabolic Process Glycolytic Process Limbic System Development Cellular Response To Hypoxia Telencephalon Cell Migration Cellular Response To Decreased Oxygen Levels
Tagcloud ?		acp acyl amido biosynthetic catalyse catalyses gcv homologue lagged lds ligases lip3 lipl lipm lipoate lipoyl lpl lpla lpls octanoate octanoyl octanoyltransferase oxoglutarate pdh pyruvate salvaged subtilis surprising transfers	a25 anisomycin ap b42 calyculin changing cm cotransfection dexamethasone dichloroisocoumarin dithiocarbamate flanking fos heterogenous interferon jak jun microm nitrite nos okadaic oxide panepoxydone phenylarsine pyrrolidine resting stat1alpha tyrphostin unlikely
Tagcloud (Difference) ?		acp acyl amido biosynthetic catalyse catalyses gcv homologue lagged lds ligases lip3 lipl lipm lipoate lipoyl lpl lpla lpls octanoate octanoyl octanoyltransferase oxoglutarate pdh pyruvate salvaged subtilis surprising transfers	a25 anisomycin ap b42 calyculin changing cm cotransfection dexamethasone dichloroisocoumarin dithiocarbamate flanking fos heterogenous interferon jak jun microm nitrite nos okadaic oxide panepoxydone phenylarsine pyrrolidine resting stat1alpha tyrphostin unlikely
Tagcloud (Intersection) ?