TMPRSS2 and BNIP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMPRSS2	BNIP2
Description		transmembrane serine protease 2	BCL2 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Membrane Extracellular Exosome	Nuclear Envelope Nucleolus Cytoplasm Centriole Cytosol Spindle Pole Centrosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	GTPase Activator Activity Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Protein Autoprocessing Viral Translation Positive Regulation Of Viral Entry Into Host Cell Entry Receptor-mediated Virion Attachment To Host Cell	Blastocyst Development Apoptotic Process Centrosome Cycle Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Cell Differentiation Response To Oxygen-glucose Deprivation
Pathways		Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion	Myogenesis Myogenesis
Drugs		Bromhexine Camostat MM3122
Diseases		Prostate cancer
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		60 interacting genes: ACE2 ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF UPK2 VAMP5 ZFPL1	56 interacting genes: ABHD4 AGPAT3 APOBEC3B ARHGAP1 ARHGAP8 BCL2 BNIP3 BNIP5 BNIPL CDC42 CHODL CPLX4 CREB3 CYB5R3 DESI2 DGAT2L6 DHRS1 EI24 ERLIN1 FAHD1 FAM209A FAM3C FATE1 FGFR1 FRK GORAB GPR152 GPX8 GRAMD2A GSC2 HSPA1B KCNK5 KLC1 LDLRAD1 LIME1 LMNA MEOX1 MEOX2 MYO5B NCBP1 OTX2 PEX12 PLEKHO1 RASGRP4 SFT2D2 SIN3A SLC35E3 SLC39A9 SLC7A14 SYT1 SYT2 TMEM237 TMPRSS2 TMX2 UPK1B YIF1A
Entrez ID		7113	663
HPRD ID		03637	04481
Ensembl ID		ENSG00000184012	ENSG00000140299
Uniprot IDs		A0A7I2V474 O15393	H7C096 Q12982
PDB IDs		7MEQ 7XYD 7Y0E 7Y0F 8HD8 8JHZ 8JI0 8S0L 8S0M 8S0N 8V04 8V1F 8VGT 8Y1D 8Y1E 8Y7X 8Y7Y 8Y87 8Y88 8Y89 8Y8A 8Y8B 8YOY 8YQQ 9IZN
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Protein Binding Positive Regulation Of Monocyte Chemotactic Protein-1 Production Alkenylglycerophosphocholine Hydrolase Activity Endoplasmic Reticulum Respiratory Burst After Phagocytosis Response To Bacterium Cytokine Activity Positive Regulation Of Chemokine Production CCR6 Chemokine Receptor Binding Killing By Host Of Symbiont Cells Chloride Channel Inhibitor Activity SNAP Receptor Activity Biological Process Involved In Interaction With Symbiont Identical Protein Binding Regulation Of Chemokine Production Respiratory Burst Involved In Defense Response	Protein Binding Endoplasmic Reticulum Membrane Regulation Of Growth Regulation Of Cell Growth Negative Regulation Of Endocytic Recycling Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Endoplasmic Reticulum Somite Specification Positive Regulation Of Growth Positive Regulation Of Cell Growth Regulation Of Vesicle Fusion Chromaffin Granule Membrane Mitochondrial Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?