VMA22 and ALOX15B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VMA22	ALOX15B
Description		vacuolar ATPase assembly factor VMA22	arachidonate 15-lipoxygenase type B
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Vacuole Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Cytoplasmic Vesicle	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Unfolded Protein Binding	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Arachidonate 15-lipoxygenase Activity Dioxygenase Activity Linoleate 9S-lipoxygenase Activity
	Biological Process	Intracellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process
Pathways		RHOA GTPase cycle	Synthesis of 15-eicosatetraenoic acid derivatives
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: ABI2 ALOX15B APP CSNK2B MIS18A NTAQ1 PLK1 PRKCZ TK1	9 interacting genes: CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21 VMA22
Entrez ID		84317	247
HPRD ID		14428	04739
Ensembl ID		ENSG00000136710	ENSG00000179593
Uniprot IDs		B8ZZ99 Q96NT0	O15296
PDB IDs			4NRE 7LAF 8VIY
Enriched GO Terms of Interacting Partners?		Phosphate-containing Compound Metabolic Process Cytosol Phosphorylation Protein Phosphorylation Identical Protein Binding Nucleus Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Chemokine Production Endocannabinoid Signaling Pathway Linoleate 9S-lipoxygenase Activity Linoleate 13S-lipoxygenase Activity Anchoring Junction Cannabinoid Biosynthetic Process Arachidonate 15-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Cannabinoid Signaling Pathway Positive Regulation Of Chemokine Production Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Modulation Of Excitatory Postsynaptic Potential Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Modification Process Protein Kinase CK2 Complex Protein Serine/threonine Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Protein Localization To Chromosome Synaptonemal Complex Disassembly Golgi Inheritance DNA Synthesis Involved In Mitotic DNA Replication	Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Lipoprotein Transport Nuclear Receptor Activity MRNA Transcription By RNA Polymerase II DNA Binding Domain Binding LBD Domain Binding MRNA Transcription Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Alpha-actinin Binding RNA Polymerase II Transcription Regulator Complex TRNA Threonylcarbamoyladenosine Metabolic Process Hormone-mediated Signaling Pathway Monocyte Differentiation Retinoic Acid Binding Identical Protein Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Cholesterol Efflux Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nucleic Acid Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Intracellular Receptor Signaling Pathway Protein Catabolic Process Transcription Coregulator Binding Regulation Of Cholesterol Efflux Macromolecule Metabolic Process Positive Regulation Of Binding Transcription Cis-regulatory Region Binding RNA Metabolic Process Transcription By RNA Polymerase II Regulation Of Cholesterol Transport Sertoli Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Lipid Transport Enzyme Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Adiponectin Secretion Negative Regulation Of Innate Immune Response Negative Regulation Of Response To Cytokine Stimulus DNA-templated Transcription Response To Retinoic Acid Macromolecule Catabolic Process
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