PLAUR and SURF2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PLAUR	SURF2
Description		plasminogen activator, urokinase receptor	surfeit 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extrinsic Component Of Membrane Specific Granule Membrane Cell Projection Anchoring Junction Side Of Membrane Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex	Nucleoplasm Nucleolus Plasma Membrane Nuclear Speck
	Molecular Function	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Plasminogen Activation Regulation Of Cell Adhesion Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Urokinase Tenecteplase WX-UK1 Lanoteplase
Diseases
GWAS		Basophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Activated partial thromboplastin time ( 22703881) Malaria ( 31844061)
Interacting Genes		22 interacting genes: CRYAA DYRK1A EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN	6 interacting genes: APP B4GALT3 NPTN PLAUR PRNP ZNF331
Entrez ID		5329	6835
HPRD ID		01421	15948
Ensembl ID		ENSG00000011422	ENSG00000148291
Uniprot IDs		M0R1I2 Q03405	Q15527
PDB IDs		1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI 7E17 7V63
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Tyrosine Kinase Activity Focal Adhesion Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Wound Healing Type II Interferon-mediated Signaling Pathway Regulation Of Fibrinolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Blood Coagulation Cell Surface Receptor Signaling Pathway Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Receptor-mediated Endocytosis Regulation Of Multicellular Organismal Process Cell Motility Protein Phosphorylation Regulation Of Cell Adhesion Membrane Raft Phosphorylation Extracellular Space Integrin-mediated Signaling Pathway Regulation Of Collagen Catabolic Process Regulation Of Protein Metabolic Process Cell Migration Plasma Membrane Endocytosis Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Motility Interleukin-11-mediated Signaling Pathway Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Protein Kinase Activity Integrin Binding Negative Regulation Of Coagulation Regulation Of Locomotion Protein Complex Involved In Cell-matrix Adhesion Response To Amyloid-beta Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Developmental Process Positive Regulation Of Wound Healing Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT	Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Extrinsic Component Of Membrane Cell Surface Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Molecular Function Activator Activity Cellular Response To Copper Ion Response To Copper Ion Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Phosphate Metabolic Process Neuron Recognition Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Calcium-mediated Signaling External Side Of Plasma Membrane Regulation Of Protein Processing Response To Amyloid-beta Regulation Of Protein Maturation Regulation Of Proteolysis Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Neuron Apoptotic Process Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Urokinase Plasminogen Activator Receptor Activity Type 8 Metabotropic Glutamate Receptor Binding Dendrite Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Modulation Of Chemical Synaptic Transmission Regulation Of Calcium-mediated Signaling Protein-folding Chaperone Binding Intracellular Chemical Homeostasis Acetylcholine Receptor Activator Activity Regulation Of Phosphorus Metabolic Process Regulation Of Type II Interferon Production Lipoprotein Particle Positive Regulation Of Protein Import Urokinase Plasminogen Activator Signaling Pathway Memory
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