PLAUR and ITGAM

Number of citations of the paper that reports this interaction (PMID 10744708)
25

Data Source:
HPRD (in vivo, in vitro)

		PLAUR	ITGAM
Gene Name		plasminogen activator, urokinase receptor	integrin, alpha M (complement component 3 receptor 3 subunit)
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome Invadopodium Membrane	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	C-terminal Protein Lipidation Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction Blood Coagulation Attachment Of GPI Anchor To Protein Regulation Of Proteolysis Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration
Pathways		Post-translational protein modification Attachment of GPI anchor to uPAR Dissolution of Fibrin Clot Post-translational modification: synthesis of GPI-anchored proteins	Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase
Diseases
GWAS			Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		20 interactors: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN	18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1
Entrez ID		5329	3684
HPRD ID		01421	00411
Ensembl ID		ENSG00000011422	ENSG00000169896
Uniprot IDs		M0R1I2 Q03405	P11215
PDB IDs		1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74	1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76
Enriched GO Terms of Interacting Partners?		Cell Motility Cell Migration Locomotion Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Collagen Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Regulation Of Cell Migration Regulation Of Smooth Muscle Cell Migration Defense Response Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Developmental Process Endocytosis Regulation Of Apoptotic Process Negative Regulation Of Blood Coagulation Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Coagulation Regulation Of Cell Death Blood Coagulation Hemostasis Protein Autophosphorylation Negative Regulation Of Wound Healing Cell Adhesion Leukocyte Migration Innate Immune Response Regulation Of Innate Immune Response Cell Adhesion Mediated By Integrin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Blood Coagulation Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Vesicle-mediated Transport Activated T Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cellular Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Cell Adhesion Extracellular Matrix Organization	Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade
Tagcloud ?		alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?		alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?