PLAUR and ITGAM

Number of citations of the paper that reports this interaction (PubMedID 10744708)
0

Data Source:
HPRD (in vitro, in vivo)

		PLAUR	ITGAM
Description		plasminogen activator, urokinase receptor	integrin subunit alpha M
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extrinsic Component Of Membrane Specific Granule Membrane Cell Projection Anchoring Junction Side Of Membrane Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Signaling Receptor Activity Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Plasminogen Activation Regulation Of Cell Adhesion Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Microglial Cell Activation Immune System Process Complement Receptor Mediated Signaling Pathway Response To Ischemia Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Metabolic Process Ectodermal Cell Differentiation Forebrain Development Response To Estradiol Positive Regulation Of Superoxide Anion Generation Heterotypic Cell-cell Adhesion Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Response To Gram-positive Bacterium Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Microglial Cell Mediated Cytotoxicity Response To Curcumin
Pathways		Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot	Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs		Urokinase Tenecteplase WX-UK1 Lanoteplase
Diseases
GWAS		Basophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 24871463 32771030 28714469 27399966 26606652 26502338 18204098 23273568 21408207 19838195 19165918 18204446) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Interacting Genes		22 interacting genes: CRYAA DYRK1A EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN	56 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 GPX8 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35H1 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2
Entrez ID		5329	3684
HPRD ID		01421	00411
Ensembl ID		ENSG00000011422	ENSG00000169896
Uniprot IDs		M0R1I2 Q03405	P11215
PDB IDs		1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI 7E17 7V63	1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW 7AKK 7P2D 7USL 7USM 8CE6 8CE9 8VOH 8VOI
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Tyrosine Kinase Activity Focal Adhesion Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Wound Healing Type II Interferon-mediated Signaling Pathway Regulation Of Fibrinolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Blood Coagulation Cell Surface Receptor Signaling Pathway Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Receptor-mediated Endocytosis Regulation Of Multicellular Organismal Process Cell Motility Protein Phosphorylation Regulation Of Cell Adhesion Membrane Raft Phosphorylation Extracellular Space Integrin-mediated Signaling Pathway Regulation Of Collagen Catabolic Process Regulation Of Protein Metabolic Process Cell Migration Plasma Membrane Endocytosis Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Motility Interleukin-11-mediated Signaling Pathway Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Protein Kinase Activity Integrin Binding Negative Regulation Of Coagulation Regulation Of Locomotion Protein Complex Involved In Cell-matrix Adhesion Response To Amyloid-beta Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Developmental Process Positive Regulation Of Wound Healing Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT	Membrane External Side Of Plasma Membrane Regulation Of Cellular Extravasation Adhesion Of Symbiont To Host Cell Virion Attachment To Host Cell Integrin Binding Adhesion Of Symbiont To Host Positive Regulation Of Cellular Extravasation Endoplasmic Reticulum Membrane Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Cell-cell Adhesion ICAM-3 Receptor Activity Peptide Antigen Transport Cell Surface Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Apoptotic Signaling Pathway Protein Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Receptor-mediated Virion Attachment To Host Cell Heterotypic Cell-cell Adhesion Intracellular Transport Of Virus Endoplasmic Reticulum Host Cell Serine-type Endopeptidase Complex Virion Binding Plasma Membrane Cell Adhesion Complement Component C3b Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Blood Microparticle
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