PLAUR

Name	plasminogen activator, urokinase receptor
Structure
Novel Interactors	1 novel interactors: PDGFRB
Interactors	22 interactors: CRYAA DYRK1A EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extrinsic Component Of Membrane Specific Granule Membrane Cell Projection Anchoring Junction Side Of Membrane Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Plasminogen Activation Regulation Of Cell Adhesion Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways	Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs	Urokinase Tenecteplase WX-UK1 Lanoteplase
GWAS	Basophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol levels ( 32203549 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 27863252 )
Entrez ID	5329
HPRD ID	01421
Ensembl ID	ENSG00000011422
Uniprot IDs	M0R1I2 Q03405
PDB IDs	1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI 7E17 7V63
GO Terms Enriched among Interactors ?	Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Tyrosine Kinase Activity Focal Adhesion Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Wound Healing Type II Interferon-mediated Signaling Pathway Regulation Of Fibrinolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Blood Coagulation Cell Surface Receptor Signaling Pathway Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Receptor-mediated Endocytosis Regulation Of Multicellular Organismal Process Cell Motility Protein Phosphorylation Regulation Of Cell Adhesion Membrane Raft Phosphorylation Extracellular Space Integrin-mediated Signaling Pathway Regulation Of Collagen Catabolic Process Regulation Of Protein Metabolic Process Cell Migration Plasma Membrane Endocytosis Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Motility Interleukin-11-mediated Signaling Pathway Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Protein Kinase Activity Integrin Binding Negative Regulation Of Coagulation Regulation Of Locomotion Protein Complex Involved In Cell-matrix Adhesion Response To Amyloid-beta Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Developmental Process Positive Regulation Of Wound Healing Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT