PLAUR and MMP12

Number of citations of the paper that reports this interaction (PMID 12195704)
17

Data Source:
HPRD (in vitro, in vivo)

		PLAUR	MMP12
Gene Name		plasminogen activator, urokinase receptor	matrix metallopeptidase 12 (macrophage elastase)
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome Invadopodium Membrane	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Receptor Activity Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	C-terminal Protein Lipidation Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction Blood Coagulation Attachment Of GPI Anchor To Protein Regulation Of Proteolysis Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Pathways		Post-translational protein modification Attachment of GPI anchor to uPAR Dissolution of Fibrin Clot Post-translational modification: synthesis of GPI-anchored proteins	Collagen degradation Degradation of the extracellular matrix
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase	Acetohydroxamic Acid Marimastat CP-271485 PF-00356231 Batimastat 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4\'-Ethoxy-1,1\'-Biphenyl-4-Yl)-4-Oxobutanoic Acid (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE N-(biphenyl-4-ylsulfonyl)-D-leucine N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide N-oxo-2-(phenylsulfonylamino)ethanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[(4-methoxyphenyl)sulfonyl]-D-alanine
Diseases
GWAS			Alzheimer's disease ( 22832961)
Protein-Protein Interactions		20 interactors: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN	5 interactors: APP F12 LPA PLAUR TFPI
Entrez ID		5329	4321
HPRD ID		01421	03027
Ensembl ID		ENSG00000011422
Uniprot IDs		M0R1I2 Q03405	P39900
PDB IDs		1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74	1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2HU6 2JXY 2K2G 2K9C 2KRJ 2OXU 2OXW 2OXZ 2POJ 2W0D 2WO8 2WO9 2WOA 2Z2D 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 3F19 3F1A 3LIK 3LIL 3LIR 3LJG 3LK8 3LKA 3N2U 3N2V 3NX7 3RTS 3RTT 3TS4 3TSK 3UVC 4EFS 4GQL 4GR0 4GR3 4GR8 4GUY 4H30 4H49 4H76 4H84 4I03 4IJO
Enriched GO Terms of Interacting Partners?		Cell Motility Cell Migration Locomotion Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Collagen Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Regulation Of Cell Migration Regulation Of Smooth Muscle Cell Migration Defense Response Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Developmental Process Endocytosis Regulation Of Apoptotic Process Negative Regulation Of Blood Coagulation Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Coagulation Regulation Of Cell Death Blood Coagulation Hemostasis Protein Autophosphorylation Negative Regulation Of Wound Healing Cell Adhesion Leukocyte Migration Innate Immune Response Regulation Of Innate Immune Response Cell Adhesion Mediated By Integrin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Blood Coagulation Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Vesicle-mediated Transport Activated T Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cellular Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Cell Adhesion Extracellular Matrix Organization	Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Urokinase Plasminogen Activator Signaling Pathway Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Factor XII Activation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Protein Activation Cascade Lipoprotein Metabolic Process Collateral Sprouting In Absence Of Injury Protein Metabolic Process Positive Regulation Of Fibrinolysis Blood Coagulation, Extrinsic Pathway Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Plasminogen Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Lipid Metabolic Process Neuron Remodeling Response To Stress Protein Autoprocessing Plasma Kallikrein-kinin Cascade Attachment Of GPI Anchor To Protein Regulation Of Fibrinolysis Regulation Of Metabolic Process Blood Coagulation, Intrinsic Pathway Response To Misfolded Protein Cellular Copper Ion Homeostasis Positive Regulation Of Protein Processing
Tagcloud ?		alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1	2h behind carbethoxyamino carbodithioate chromen constitutive coumarin cpp cxcl12 derivatives docked docking evidently fifth great hcc hepatocellular invasion methylpyrrolidine oxo p50 p65 reporting scoring suppress survivin tumorigenesis worldwide yl
Tagcloud (Difference) ?		alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes utrs zeb1	2h behind carbethoxyamino carbodithioate chromen constitutive coumarin cpp cxcl12 derivatives docked docking evidently fifth great hcc hepatocellular invasion methylpyrrolidine oxo p50 p65 reporting scoring suppress survivin worldwide yl
Tagcloud (Intersection) ?		tumorigenesis