JOSD2 and PLA2G2A

Number of citations of the paper that reports this interaction (PMID 22118674)
23

Data Source:
BioGRID (enzymatic study)

		JOSD2	PLA2G2A
Gene Name		Josephin domain containing 2	phospholipase A2, group IIA (platelets, synovial fluid)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-specific Protease Activity Omega Peptidase Activity	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Proteolysis Protein Deubiquitination	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Somatic Stem Cell Maintenance Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Phosphatidic Acid Metabolic Process Glycerophospholipid Biosynthetic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium
Pathways			Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs			Indomethacin Diclofenac Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid Elaidoylamide 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid Suramin
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PLA2G2A STUB1 UBC	24 interactors: ALOX12 BAG6 CEP70 CRMP1 DCN JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM
Entrez ID		126119	5320
HPRD ID		15297	01397
Ensembl ID		ENSG00000161677	ENSG00000188257
Uniprot IDs		Q7Z7N5 Q8TAC2	P14555
PDB IDs			1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Ubiquitination Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Protein Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Proteolysis Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Modification-dependent Protein Catabolic Process Low-density Lipoprotein Particle Remodeling Regulation Of Glucocorticoid Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Misfolded Or Incompletely Synthesized Protein Catabolic Process Phosphatidylinositol Acyl-chain Remodeling Cellular Response To Misfolded Protein Cellular Response To Growth Factor Stimulus Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling DNA Repair Response To Growth Factor Protein Modification By Small Protein Conjugation Response To Misfolded Protein Protein Catabolic Process Regulation Of Proteolysis Phosphatidylethanolamine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Notch Receptor Processing Virion Assembly	Protein Modification By Small Protein Removal Protein Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Proteolysis Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K48-linked Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Dermatan Sulfate Biosynthetic Process Regulation Of Phospholipase A2 Activity Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Chondroitin Sulfate Biosynthetic Process Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Protein Stability Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukotriene Metabolic Process Cellular Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Icosanoid Biosynthetic Process Negative Regulation Of Arachidonic Acid Secretion Lipoxin B4 Biosynthetic Process Leukotriene A4 Metabolic Process Cellular Response To DNA Damage Stimulus Unsaturated Fatty Acid Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Negative Regulation Of Protein Metabolic Process
Tagcloud ?			1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Difference) ?			1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Intersection) ?