PLA2G1B and CSF3R

Number of citations of the paper that reports this interaction (PMID 14557262)
3

Data Source:
HPRD (in vitro)

		PLA2G1B	CSF3R
Gene Name		phospholipase A2, group IB (pancreas)	colony stimulating factor 3 receptor (granulocyte)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Secretory Granule	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Phospholipase A2 Activity Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity	Receptor Activity Cytokine Receptor Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Glucose Transport Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Multicellular Organismal Lipid Catabolic Process Small Molecule Metabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylcholine Metabolic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Amelogenesis
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs			Pegfilgrastim Filgrastim
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BGN CSF3R PLA2G2A PLAA SOCS2	19 interactors: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
Entrez ID		5319	1441
HPRD ID		01396	00737
Ensembl ID		ENSG00000170890	ENSG00000119535
Uniprot IDs		P04054	Q99062
PDB IDs		1YSK 3ELO	1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?		Defense Response Dermatan Sulfate Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phospholipid Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Phosphatidylinositol Acyl-chain Remodeling Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Amelogenesis Cytokine-mediated Signaling Pathway Negative Regulation Of JAK-STAT Cascade Phosphatidylethanolamine Acyl-chain Remodeling Chondroitin Sulfate Biosynthetic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Growth Hormone Receptor Signaling Pathway Chondroitin Sulfate Proteoglycan Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Phosphatidylserine Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune Response Leukocyte Migration Regulation Of Immune Response Response To Peptide Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Motility Immune System Process Defense Response Innate Immune Response Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organonitrogen Compound Response To Organic Substance Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Locomotion Response To Hormone Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Growth Hormone Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction JAK-STAT Cascade Blood Coagulation Hemostasis Regulation Of Intracellular Signal Transduction Signal Transduction Cytokine-mediated Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus
Tagcloud ?		adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Difference) ?		adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Intersection) ?