PLA2G1B and BGN

Number of citations of the paper that reports this interaction (PMID 9848887)
7

Data Source:
HPRD (in vitro)

		PLA2G1B	BGN
Gene Name		phospholipase A2, group IB (pancreas)	biglycan
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Secretory Granule	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Phospholipase A2 Activity Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity	Extracellular Matrix Structural Constituent Glycosaminoglycan Binding Extracellular Matrix Binding
	Biological Process	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Glucose Transport Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Multicellular Organismal Lipid Catabolic Process Small Molecule Metabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylcholine Metabolic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity	Blood Vessel Remodeling Carbohydrate Metabolic Process Biological_process Pathogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BGN CSF3R PLA2G2A PLAA SOCS2	16 interactors: APOB APP BMP4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HDL3 JPH3 MFAP2 PLA2G1B TGFB1 TNF WISP1
Entrez ID		5319	633
HPRD ID		01396	02359
Ensembl ID		ENSG00000170890	ENSG00000182492
Uniprot IDs		P04054	B4DNL4 P21810 Q8NAB7
PDB IDs		1YSK 3ELO
Enriched GO Terms of Interacting Partners?		Defense Response Dermatan Sulfate Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phospholipid Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Phosphatidylinositol Acyl-chain Remodeling Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Amelogenesis Cytokine-mediated Signaling Pathway Negative Regulation Of JAK-STAT Cascade Phosphatidylethanolamine Acyl-chain Remodeling Chondroitin Sulfate Biosynthetic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Growth Hormone Receptor Signaling Pathway Chondroitin Sulfate Proteoglycan Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Phosphatidylserine Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation	Extracellular Matrix Organization Extracellular Structure Organization Locomotion Anatomical Structure Morphogenesis Multicellular Organismal Metabolic Process Movement Of Cell Or Subcellular Component Extracellular Matrix Disassembly Response To External Stimulus Organ Morphogenesis Protein Localization To Nucleus Collagen Catabolic Process Cell Morphogenesis Involved In Differentiation Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Leukocyte Migration System Development Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Myoblast Differentiation Response To Hormone Cellular Response To Growth Factor Stimulus Bone Morphogenesis Chemotaxis Multicellular Organismal Development Response To Growth Factor Immune System Process Anatomical Structure Development Cell Morphogenesis Organ Development Salivary Gland Morphogenesis Endochondral Ossification Gland Morphogenesis Regulation Of Myoblast Differentiation Salivary Gland Development Negative Regulation Of Muscle Cell Differentiation Cellular Response To Acid Chemical Cellular Response To Lipid Cellular Response To Transforming Growth Factor Beta Stimulus Blood Coagulation Hemostasis Developmental Process Exocrine System Development Response To Transforming Growth Factor Beta Platelet Activation Cartilage Development Common-partner SMAD Protein Phosphorylation Cell Migration Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cardiovascular System Development
Tagcloud ?		adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate	bambara bean beverage bgnm bgns boiled cow cowpea crop crops drought eaten fermented groundnut irritable legume legumes neglected nutritious probiotic probiotics relish roasted salted snack subterraenea traced verdc vigna
Tagcloud (Difference) ?		adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate	bambara bean beverage bgnm bgns boiled cow cowpea crop crops drought eaten fermented groundnut irritable legume legumes neglected nutritious probiotic probiotics relish roasted salted snack subterraenea traced verdc vigna
Tagcloud (Intersection) ?