DSG2 and DSC1

Number of citations of the paper that reports this interaction (PMID 9214392)
48

Data Source:
HPRD (in vivo, in vitro)

		DSG2	DSC1
Gene Name		desmoglein 2	desmocollin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Extracellular Vesicular Exosome	Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding	Calcium Ion Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Response To Progesterone Maternal Process Involved In Female Pregnancy Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Multiple sclerosis ( 23412934)
Protein-Protein Interactions		5 interactors: DSC1 DSC2 JUP PKP2 PKP3	8 interactors: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5
Entrez ID		1829	1823
HPRD ID		00516	00511
Ensembl ID		ENSG00000046604	ENSG00000134765
Uniprot IDs		Q14126	Q08554 Q9HB00
PDB IDs		2YQG
Enriched GO Terms of Interacting Partners?		Desmosome Assembly Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cell Adhesion Regulation Of Striated Muscle Contraction Action Potential Cell-cell Junction Assembly Single Organismal Cell-cell Adhesion Regulation Of Muscle Contraction Regulation Of Heart Contraction Cell Junction Assembly Cell-cell Junction Organization Regulation Of Membrane Potential Regulation Of Actin Filament-based Process Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Regulation Of Cellular Component Movement Protein Localization To Plasma Membrane Endothelial Cell-cell Adhesion Adherens Junction Maintenance Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Plasma Membrane Organization Establishment Of Protein Localization To Membrane Cellular Response To Indole-3-methanol Maintenance Of Organ Identity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Intermediate Filament Bundle Assembly Regulation Of Tight Junction Assembly Cytoskeletal Anchoring At Plasma Membrane Protein Localization To Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Endomembrane System Organization Cell-cell Signaling Involved In Cardiac Conduction Intermediate Filament Organization Regulation Of Cell Fate Specification Cellular Component Assembly Gap Junction Assembly Cellular Component Maintenance Regulation Of Cell Fate Commitment	Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cell-cell Junction Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Cell Adhesion Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Action Potential Regulation Of Striated Muscle Contraction Intermediate Filament Organization Cell-cell Junction Assembly Regulation Of Muscle Contraction Regulation Of Heart Contraction Intermediate Filament Cytoskeleton Organization Cell Junction Assembly Intermediate Filament-based Process Regulation Of Membrane Potential Intermediate Filament Bundle Assembly Adherens Junction Organization Regulation Of Actin Filament-based Process Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Response To Progesterone Ventricular Cardiac Muscle Tissue Development Cellular Component Assembly Cardiac Muscle Tissue Morphogenesis Apoptotic Process Programmed Cell Death Muscle Tissue Morphogenesis Cell Death Death Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cytoskeleton Organization Establishment Of Protein Localization To Plasma Membrane Maternal Process Involved In Female Pregnancy Cardiac Ventricle Development Ventricular Compact Myocardium Morphogenesis Endothelial Cell-cell Adhesion Adherens Junction Maintenance Cardiac Chamber Development
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes