DSG2 and DSC2

Number of citations of the paper that reports this interaction (PubMedID 11853539)
40

Data Source:
HPRD (in vitro)

		DSG2	DSC2
Description		desmoglein 2	desmocollin 2
Image
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Extracellular Exosome Anchoring Junction	Cornified Envelope Endoplasmic Reticulum Plasma Membrane Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cytoplasmic Vesicle Extracellular Exosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Epithelial To Mesenchymal Transition Response To Progesterone Negative Regulation Of Apoptotic Process Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Cell Adhesion Maternal Process Involved In Female Pregnancy Mesenchymal To Epithelial Transition Stem Cell Proliferation Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Sprouting Angiogenesis	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of P38MAPK Cascade
Pathways		Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738)
Interacting Genes		5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3	6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3
Entrez ID		1829	1824
HPRD ID		00516	00512
Ensembl ID		ENSG00000046604	ENSG00000134755
Uniprot IDs		A0AAQ5BGT2 Q14126	A0A3B3ISU0 A0AAQ5BGT5 Q02487
PDB IDs		2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7A7D 7AGF 7AGG 8QJX 8QJY 8QK3	5ERP 5J5J 7A7D
Enriched GO Terms of Interacting Partners?		Desmosome Cornified Envelope Desmosome Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Organization Adherens Junction Cell Junction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Adhesion Regulation Of Action Potential Homotypic Cell-cell Adhesion Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Cell Junction Organization Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Cell-cell Junction Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Assembly Protein Localization To Membrane Cadherin Binding Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Gamma-catenin-TCF7L2 Complex Localization Within Membrane Cell Adhesion Molecule Binding Maintenance Of Protein Localization At Cell Tip Regulation Of System Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Desmosome Maintenance Intermediate Filament Catenin-TCF7L2 Complex	Desmosome Cornified Envelope Desmosome Organization Cell-cell Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Assembly Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Cell Junction Cell Junction Organization Homotypic Cell-cell Adhesion Cell Adhesion Regulation Of Cardiac Muscle Contraction Cell Junction Assembly Gamma-catenin Binding Cell Adhesion Molecule Binding Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Epithelial Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Regulation Of Muscle Contraction Maternal Process Involved In Female Pregnancy Response To Progesterone Protein Localization To Plasma Membrane Adherens Junction Regulation Of Heart Contraction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cytoplasm Cellular Component Assembly Regulation Of System Process Protein Localization To Cell Periphery Calcium Ion Binding Regulation Of Muscle System Process Regulation Of Blood Circulation Purkinje Myocyte Development
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