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TCF4 and FAM124B
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
TCF4
FAM124B
Gene Name
transcription factor 4
family with sequence similarity 124B
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Transcription Factor Complex
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase Recruiting Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
TFIIB-class Binding Transcription Factor Activity
TFIIB-class Transcription Factor Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Protein Heterodimerization Activity
E-box Binding
Protein Binding
Biological Process
DNA-templated Transcription, Initiation
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein-DNA Complex Assembly
Pathways
CDO in myogenesis
Myogenesis
Drugs
Diseases
GWAS
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) (
23453885
)
Diabetic retinopathy (
21441570
)
Fuchs's corneal dystrophy (
20825314
)
Obesity (early onset extreme) (
23563609
)
Schizophrenia (
21926974
19571808
19571811
22688191
23894747
)
Sclerosing cholangitis and ulcerative colitis (combined) (
22821403
)
Protein-Protein Interactions
173 interactors:
AES
AQP1
AR
ARHGEF1
ARMC7
ASCL1
ASCL3
ASCL4
ASPSCR1
ATP6V1B2
BCAS2
BCL2L2
BZRAP1
C19orf66
C1orf109
C9orf171
CABP5
CALM1
CALM2
CALM3
CCDC101
CDC73
CDKN1A
CDKN2C
CHAF1A
CHCHD2
CHIC2
CKS1B
CTBP1
CTNNB1
DDX6
DEF6
DGCR6
DMRT3
EFHC1
EIF4E2
EIF4EBP1
EP300
EPB41L3
EPHB6
EXOSC1
FAH
FAM124B
FAM74A4
FERD3L
FLAD1
FLNA
FRS3
GEM
GLRX3
GNG10
GOLGA8EP
GOLGA8F
GORASP2
GTF3C5
GUCD1
HAND2
HAT1
HBP1
HIC1
HSPB7
ID1
ID2
ID3
ID4
INS
JUN
JUP
KCTD14
KLC3
KLHL32
LASP1
LENG1
LGALS14
LMO1
LMO4
LNPEP
LYL1
MAD2L2
MAGOHB
MAPKBP1
MATN3
MEMO1
MEN1
MLLT6
MORN4
MRFAP1L1
MRPL10
MSC
MSRB3
MVP
MYO5B
MYOD1
NCK2
NDOR1
NEK6
NEK8
NEU4
NEUROD1
NEUROG1
NME7
NMUR2
NOL9
NR2C2AP
NR4A1
NUDT10
ORC4
OSGIN1
OTUD4
PARK2
PARP1
PATE1
PBLD
PIN1
PLEKHN1
POLR1A
POLR1C
PPIA
PPIL1
PPP1R18
PRKAA2
PRKAB2
PSEN1
PSMA1
PSMG2
PTF1A
PTGER3
RAB41
RABIF
RECK
RELA
REXO1L6P
RNF138
RSPH14
RUNX1T1
SCOC
SEC14L4
SIGLEC6
SLC39A13
SLC4A1AP
SMCP
SMOC1
SPATC1L
SPG21
SRSF2
STAMBPL1
STK16
STX11
SUMO1
SZT2
TAL1
TAL2
TAPBPL
TCEA2
TCF3
TCL1A
TLE1
TMEM213
TRAPPC2L
TSSC4
TSSK3
TWIST2
TXNL4B
USP4
UTP23
VPS28
XRCC5
XRCC6
ZDHHC24
ZNF124
ZNF205-AS1
ZNF417
ZNF587
29 interactors:
ADAMTSL4
AES
BIRC7
CARD9
CCDC85B
EFEMP2
GOLGA2
KCTD6
KCTD9
KIAA1958
KRT19
KRT31
KRT40
KRTAP10-3
KRTAP10-7
KRTAP10-9
KRTAP5-9
LZTS2
MDFI
MKRN3
NOTCH2NL
RBPMS
RINT1
SSX2IP
TCF4
TRIM37
TRIM54
TRIP6
USHBP1
Entrez ID
6925
79843
HPRD ID
03780
08663
Ensembl ID
ENSG00000196628
ENSG00000124019
Uniprot IDs
B3KVA4
E9PH57
H3BTP3
P15884
Q9H5Z6
PDB IDs
2KWF
Enriched GO Terms of Interacting Partners
?
Gene Expression
Transcription, DNA-templated
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Multicellular Organismal Development
Negative Regulation Of Cellular Protein Metabolic Process
Organ Development
Regulation Of Metabolic Process
Regulation Of Binding
System Development
Regulation Of Nitrogen Compound Metabolic Process
Developmental Process
Regulation Of Gene Expression
Central Nervous System Development
Anatomical Structure Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of DNA Binding
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Fate Commitment
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Protein Localization To Nucleus
Regulation Of Nucleocytoplasmic Transport
Regulation Of Intracellular Transport
Regulation Of Binding
Regulation Of Intracellular Protein Transport
Negative Regulation Of Binding
Regulation Of Signal Transduction
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Wnt Signaling Pathway
Positive Regulation Of JNK Cascade
Cellular Component Assembly
Regulation Of Signaling
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Cellular Localization
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Binding
Cell Differentiation Involved In Embryonic Placenta Development
Positive Regulation Of Intracellular Protein Transport
Regulation Of JNK Cascade
Activation Of JUN Kinase Activity
Regulation Of Protein Import Into Nucleus
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Localization
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Natural Killer Cell Apoptotic Process
Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Binding
Positive Regulation Of Intracellular Transport
Negative Regulation Of Fat Cell Differentiation
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of JUN Kinase Activity
Wnt Signaling Pathway
Regulation Of Protein Transport
Negative Regulation Of Protein Localization To Nucleus
Regulation Of JUN Kinase Activity
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Histone H2A-K119 Monoubiquitination
JNK Cascade
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Transcription Factor Import Into Nucleus
Regulation Of Establishment Of Protein Localization
Negative Regulation Of RNA Biosynthetic Process
Maintenance Of DNA Repeat Elements
Tagcloud
?
action
activities
agent
beta
biejiajian
catenin
cultured
cyclin
cytoplasmic
d1
downstream
expressions
fed
hepatocellular
hepg2
immunofluorescence
inhibiting
invasiveness
lowered
luciferase
mmp
pills
qrt
sera
serve
suppress
underlying
whose
wnt
Tagcloud (Difference)
?
action
activities
agent
beta
biejiajian
catenin
cultured
cyclin
cytoplasmic
d1
downstream
expressions
fed
hepatocellular
hepg2
immunofluorescence
inhibiting
invasiveness
lowered
luciferase
mmp
pills
qrt
sera
serve
suppress
underlying
whose
wnt
Tagcloud (Intersection)
?