TCF4 and MSC

Number of citations of the paper that reports this interaction (PubMedID 9584154)
81

Data Source:
HPRD (two hybrid)

		TCF4	MSC
Description		transcription factor 4	musculin
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Beta-catenin-TCF7L2 Complex Beta-catenin-TCF Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Identical Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Branchiomeric Skeletal Muscle Development Roof Of Mouth Development Diaphragm Development Cellular Response To Leukemia Inhibitory Factor
Pathways		Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Ability to confide in someone ( 29970889) Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Automobile speeding propensity ( 30643258) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Broad depression or schizophrenia ( 30626913) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal endothelial cell density ( 30894546) Corneal endothelial cell shape (percentage of hexagonally shaped cells) ( 30894546) Corneal hysteresis ( 32716492 30894546) Corneal resistance factor ( 30894546 31246245 32716492) Cutaneous leishmaniasis ( 32830257) Depression ( 33859377 29700475) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 30224653) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Feeling worry ( 29500382) Fuchs's corneal dystrophy ( 28358029 20825314) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431 29313844) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intraocular pressure ( 31798171 29617998 29235454) Irritable mood ( 29500382) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Male-pattern baldness ( 28196072) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Morning person ( 30696823) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity (early onset extreme) ( 23563609) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Pulse pressure ( 30578418) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 19571811 28991256 19571808 21926974 22688191 23894747 23974872 25056061 29483656 30285260) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Self-rated health ( 27864402) Self-reported risk-taking behaviour ( 30271922) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Surgical recurrence in Crohn's disease ( 33724339) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Type 2 diabetes ( 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Walking pace ( 33128006)	Adolescent idiopathic scoliosis ( 30395268) Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 33547301) Depression in smokers ( 30219690) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Homeostasis model assessment of insulin resistance x saturated fatty acids interaction ( 30327367) Late-onset myasthenia gravis ( 26562150) Optic disc size ( 31809533) QT interval ( 29213071) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		219 interacting genes: AIRIM ALKBH4 AQP1 AR ARHGEF1 ARHGEF5 ARL16 ARMC7 ASAP3 ASCL1 ASCL4 ASPSCR1 ATG9A ATOH7 ATP11B ATP6V1B2 BACH1 BANF2 BCAS2 BCL2L15 BCL2L2 C1orf50 C1orf56 CABP5 CALM1 CALM2 CALM3 CBFA2T2 CCNH CDC37 CDC73 CDKN1A CDKN2C CFAP77 CHAF1A CHCHD2 CHIC2 CKS1B CLCNKA COA5 CPNE2 CTBP1 CTNNB1 DAXX DDX6 DEF6 DGCR6 DMRT3 DNTT DUSP23 DUSP29 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOC8 EXOSC1 FAH FAM110A FAM124B FAM74A4 FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAT1 HBP1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 KLHL38 LASP1 LENG1 LGALS14 LHX4 LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MARF1 MATN3 MEMO1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSRB3 MVP MYO15B MYO5B MYOD1 NCK2 NDOR1 NECTIN2 NEK6 NEK8 NEU4 NEUROD1 NEUROD4 NEUROG1 NFAM1 NFKBID NHLH2 NME7 NMUR2 NOL9 NOXA1 NR2C2AP NR4A1 NUDT10 NUDT22 NXPE2 NXT2 OLFM3 ORC4 OSGIN1 OTUD4 PARP1 PATE1 PBLD PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PRKN PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RAD51D RECK RELA REXO1L6P RSPH14 RUNX1T1 SCOC SCX SDCBP SEC14L4 SGF29 SHFL SIGLEC6 SLC39A13 SLC4A1AP SMCP SMG9 SMOC1 SPATC1L SPG21 SPO11 SRSF2 STAMBPL1 STK16 STX11 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF24 TCF3 TCL1A TLE1 TLE3 TLE5 TMEM213 TP53 TRAPPC2L TRIM68 TRIML2 TSPOAP1 TSSC4 TSSK3 TSTD2 TTF2 TWIST1 TWIST2 TXNL4B UBASH3B UBE2I UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZMYND10 ZNF124 ZNF205-AS1 ZNF417 ZNF587 ZNF688	8 interacting genes: EWSR1 GORASP2 ID2 LNX1 PBX2 TCF12 TCF3 TCF4
Entrez ID		6925	9242
HPRD ID		03780	04694
Ensembl ID		ENSG00000196628	ENSG00000178860
Uniprot IDs		A0A1B0GW91 A0A1B0GWD5 B3KVA4 E9PH57 H3BPJ7 H3BTP3 P15884	O60682
PDB IDs		2KWF 6OD3 6OD4 6OD5 8OSB
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Nucleus Transcription Regulator Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Transcription Corepressor Activity Cell Fate Commitment DNA-templated Transcription Nucleoplasm DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process BHLH Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Protein Peptidyl-prolyl Isomerization Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Disordered Domain Specific Binding Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Protein-DNA Complex Oligodendrocyte Differentiation Neuron Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Detection Of Calcium Ion Protein Kinase Binding RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Mitotic Cell Cycle DNA Binding Chromatin Binding	Protein Dimerization Activity Regulation Of Neuron Differentiation Transcription Regulator Complex E-box Binding Positive Regulation Of Neuron Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nervous System Development BHLH Transcription Factor Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Euchromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Protein Heterodimerization Activity Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process System Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of RNA Metabolic Process B Cell Differentiation Endodermal Digestive Tract Morphogenesis Developmental Process Thigmotaxis Beta-catenin-TCF7L2 Complex Vitamin D Response Element Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Bundle Of His Development Regulation Of B Cell Activation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Cell Differentiation Positive Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II TFIIB-class Transcription Factor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process B Cell Lineage Commitment Negative Regulation Of B Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of DNA-binding Transcription Factor Activity Enucleate Erythrocyte Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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