PIM1 and PPP2R4

Number of citations of the paper that reports this interaction (PMID 17297438)
16

Data Source:
BioGRID (enzymatic study)

		PIM1	PPP2R4
Gene Name		Pim-1 proto-oncogene, serine/threonine kinase	protein phosphatase 2A activator, regulatory subunit 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Manganese Ion Binding Ribosomal Small Subunit Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Receptor Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Type 2A Regulator Activity ATPase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Protein Phosphatase 2A Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Cell Proliferation Hyaluronan Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autophosphorylation	Protein Peptidyl-prolyl Isomerization Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Drugs		Adenosine monophosphate 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Rbt205 Inhibitor Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1\',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4\'-piperidine]-4-carbonitrile 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid
Diseases
GWAS			Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Protein-Protein Interactions		29 interactors: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A EPHA3 FH FXR2 HEXIM2 HIST2H3C HIST3H3 HSP90AA1 MARK3 NFATC1 NHLH1 NUMA1 PPP2R4 PTPRO SHMT1 SKP2 SND1 SNX6 TFPT ZBTB1	19 interactors: AKT1 AMOT APP AURKB BCL2 CCNG1 CCNG2 CSNK2A1 CYLD EIF4EBP1 H2AFX HDAC4 MAPT MID1 PIM1 PPP2R3A PRKCB RACGAP1 SRC
Entrez ID		5292	5524
HPRD ID		01292	02858
Ensembl ID		ENSG00000137193	ENSG00000119383
Uniprot IDs		P11309	B4DZF8 Q15257
PDB IDs		1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 4A7C 4ALU 4ALV 4ALW 4AS0 4DTK 4ENX 4ENY 4GW8 4JX3 4JX7 4K0Y 4K18 4K1B 4MBI	2G62 2HV6 2HV7 2IXM
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Innate Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transferase Activity Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Biosynthetic Process Response To Glucocorticoid Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Neuron Recognition Response To Corticosteroid Axon Guidance Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transcription, DNA-templated Mitotic Spindle Organization In Nucleus Positive Regulation Of Pro-T Cell Differentiation Slit Diaphragm Assembly Cellular Response To Chromate Regulation Of Protein Kinase Activity Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription	Regulation Of Cell Cycle Cell Cycle Regulation Of Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Cell Death Death Regulation Of Cellular Component Organization Organelle Organization Multicellular Organismal Development Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Microtubule-based Process Apoptotic Process Developmental Process Regulation Of Signaling Cellular Response To Stimulus Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Checkpoint Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Binding Response To Stress Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Nervous System Development Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Cell Growth Negative Regulation Of Mitochondrial Depolarization Regulation Of Growth Negative Regulation Of Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process
Tagcloud ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?		bm6 bx1 chimera construct ectopic ectopically effectors epo erb1 erythropoietin fdc2 fdcp1 gata interactive kit mitogenesis mitogenic mo7e notion opposing presently progenitor responsiveness scf subdomain subline synergy ways	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Intersection) ?