GPHN and ARHGEF9

Number of citations of the paper that reports this interaction (PubMedID 32203420)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		GPHN	ARHGEF9
Description		gephyrin	Cdc42 guanine nucleotide exchange factor 9
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Inhibitory Synapse Synaptic Membrane Glycinergic Synapse Postsynapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component Postsynaptic Specialization	Cytoplasm Cytosol Postsynaptic Density Synapse GABA-ergic Synapse Postsynaptic Specialization
	Molecular Function	Nucleotide Binding Catalytic Activity Signaling Receptor Binding Protein Binding ATP Binding Nitrate Reductase Activity Transferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Molybdopterin Cofactor Binding Metal Ion Binding Molecular Adaptor Activity Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Mo-molybdopterin Cofactor Biosynthetic Process Synapse Assembly Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdopterin Cofactor Biosynthetic Process Establishment Of Protein Localization Synapse Organization Synaptic Transmission, GABAergic Glycine Receptor Clustering Protein Localization To Membrane Gamma-aminobutyric Acid Receptor Clustering Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynaptic Specialization Assembly
Pathways		Molybdenum cofactor biosynthesis	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOQ GTPase cycle GABA receptor activation GABA receptor activation
Drugs		Formic acid Imidazole Propanoic acid
Diseases		Hyperekplexia	Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Appendicular lean mass ( 33097823) Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)	Male-pattern baldness ( 28196072)
Interacting Genes		15 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MITD1 MTOR PFN1 PIN1 PSMA1 SPATS1 TUBA4A	12 interacting genes: BCL6 CDC42 CFTR FAM90A1 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TBC1D22B TFIP11 TSGA10IP
Entrez ID		10243	23229
HPRD ID		04893	02337
Ensembl ID		ENSG00000171723	ENSG00000131089
Uniprot IDs		Q9NQX3	A0A1B0GWI5 A0A5F9ZHY9 A0A5F9ZI31 B1AMR3 O43307
PDB IDs		1JLJ	2YSQ
Enriched GO Terms of Interacting Partners?		GABA-ergic Synapse Microtubule Associated Complex Protein-containing Complex Binding Postsynaptic Specialization Cytoskeleton Organization Microtubule Cytoplasmic Dynein Complex Regulation Of Protein Stability Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Phosphoprotein Binding Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Glycine-gated Chloride Channel Complex Extracellularly Glycine-gated Ion Channel Activity Cis-trans Isomerase Activity Microtubule-based Process Ciliary Tip Dynein Intermediate Chain Binding Dynein Complex Grb2-Sos Complex Myosin V Complex Protein Domain Specific Binding Cytoskeleton Cytosol Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Microtubule Cytoskeleton
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