GPHN and ACADVL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GPHN	ACADVL
Description		gephyrin	acyl-CoA dehydrogenase very long chain
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Inhibitory Synapse Synaptic Membrane Glycinergic Synapse Postsynapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component Postsynaptic Specialization	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Membrane Mitochondrial Nucleoid
	Molecular Function	Nucleotide Binding Catalytic Activity Signaling Receptor Binding Protein Binding ATP Binding Nitrate Reductase Activity Transferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Molybdopterin Cofactor Binding Metal Ion Binding Molecular Adaptor Activity Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity	Fatty-acyl-CoA Binding Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Mo-molybdopterin Cofactor Biosynthetic Process Synapse Assembly Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdopterin Cofactor Biosynthetic Process Establishment Of Protein Localization Synapse Organization Synaptic Transmission, GABAergic Glycine Receptor Clustering Protein Localization To Membrane Gamma-aminobutyric Acid Receptor Clustering Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Temperature Homeostasis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Catabolic Process Response To Cold Energy Derivation By Oxidation Of Organic Compounds Epithelial Cell Differentiation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process
Pathways		Molybdenum cofactor biosynthesis	XBP1(S) activates chaperone genes Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Drugs		Formic acid Imidazole Propanoic acid
Diseases		Hyperekplexia	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Appendicular lean mass ( 33097823) Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)	Age-related hearing impairment ( 34108613) Metabolite levels ( 23823483)
Interacting Genes		15 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MITD1 MTOR PFN1 PIN1 PSMA1 SPATS1 TUBA4A	5 interacting genes: GPHN LINC01554 RPSA SOCS3 TAF1B
Entrez ID		10243	37
HPRD ID		04893	01940
Ensembl ID		ENSG00000171723	ENSG00000072778
Uniprot IDs		Q9NQX3	B3KPA6 P49748
PDB IDs		1JLJ	2UXW 3B96 7S7G
Enriched GO Terms of Interacting Partners?		GABA-ergic Synapse Microtubule Associated Complex Protein-containing Complex Binding Postsynaptic Specialization Cytoskeleton Organization Microtubule Cytoplasmic Dynein Complex Regulation Of Protein Stability Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Phosphoprotein Binding Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Glycine-gated Chloride Channel Complex Extracellularly Glycine-gated Ion Channel Activity Cis-trans Isomerase Activity Microtubule-based Process Ciliary Tip Dynein Intermediate Chain Binding Dynein Complex Grb2-Sos Complex Myosin V Complex Protein Domain Specific Binding Cytoskeleton Cytosol Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Microtubule Cytoskeleton	RNA Polymerase I Core Factor Complex Glycine Receptor Clustering Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity Laminin Receptor Activity RNA Polymerase Transcription Factor SL1 Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I Transcription Regulator Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Specialization, Intracellular Component Molybdopterin Cofactor Binding Nitrate Reductase Activity Molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Gamma-aminobutyric Acid Receptor Clustering Cellular Response To Interleukin-17 Protein Tyrosine Kinase Inhibitor Activity Glycinergic Synapse RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Branching Involved In Labyrinthine Layer Morphogenesis Postsynaptic Specialization T-helper 17 Cell Lineage Commitment Neurotransmitter-gated Ion Channel Clustering Ribosomal Small Subunit Assembly Inhibitory Synapse Transcription By RNA Polymerase I Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Laminin Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Lineage Commitment Small Ribosomal Subunit TBP-class Protein Binding RRNA Transcription CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Cytokine Receptor Binding Negative Regulation Of Receptor Signaling Pathway Via STAT Placenta Blood Vessel Development T Cell Lineage Commitment Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Synaptic Transmission, GABAergic
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