NEUROG2 and ASCL1

Number of citations of the paper that reports this interaction (PMID 8948587)
39

Data Source:
HPRD (in vitro, two hybrid)

		NEUROG2	ASCL1
Gene Name		neurogenin 2	achaete-scute family bHLH transcription factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Neuronal Cell Body
	Molecular Function	Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding E-box Binding
	Biological Process	Neuron Migration Transcription, DNA-templated Axon Guidance Central Nervous System Neuron Development Forebrain Development Cell Fate Commitment Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Noradrenergic Neuron Development Noradrenergic Neuron Fate Commitment Transcription, DNA-templated Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Neuroblast Fate Determination Neuroblast Proliferation Response To Lithium Ion Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Association Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Vestibular Nucleus Development Cerebral Cortex GABAergic Interneuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Regulation Of Epithelial Cell Differentiation Response To Retinoic Acid Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Sympathetic Nervous System Development Neuron Fate Specification Musculoskeletal Movement, Spinal Reflex Action Response To Folic Acid Subpallium Neuron Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Olfactory Pit Development Lung Epithelial Cell Differentiation Ventral Spinal Cord Interneuron Fate Commitment Lung Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Response To Epidermal Growth Factor Cellular Response To Magnetism Positive Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS			C-reactive protein ( 21300955)
Protein-Protein Interactions		1 interactors: ASCL1	8 interactors: BMP2 EP300 MEF2A MEF2C MEF2D NEUROG2 TCF4 UBQLN1
Entrez ID		63973	429
HPRD ID		06976	00011
Ensembl ID		ENSG00000178403	ENSG00000139352
Uniprot IDs		Q9H2A3	P50553
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Timing Of Subpallium Neuron Differentiation Cellular Response To Magnetism Neuroblast Fate Determination Lung Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Stomach Neuroendocrine Cell Differentiation Noradrenergic Neuron Fate Commitment Subpallium Neuron Fate Commitment Vestibular Nucleus Development Adrenal Chromaffin Cell Differentiation Olfactory Pit Development Musculoskeletal Movement, Spinal Reflex Action Noradrenergic Neuron Development Response To Magnetism Neuroblast Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Regulation Of Timing Of Neuron Differentiation Neuroendocrine Cell Differentiation Noradrenergic Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Oligodendrocyte Cell Fate Specification Sympathetic Ganglion Development Pons Development Cerebral Cortex GABAergic Interneuron Differentiation Response To Folic Acid Lung Secretory Cell Differentiation Spinal Cord Association Neuron Differentiation GABAergic Neuron Differentiation Ganglion Development Ventral Spinal Cord Interneuron Fate Commitment Forebrain Neuron Fate Commitment Regulation Of Timing Of Cell Differentiation Ventral Spinal Cord Interneuron Differentiation Regulation Of Development, Heterochronic Nose Development Reflex Glial Cell Fate Commitment Sympathetic Nervous System Development Subpallium Development Dorsal Spinal Cord Development Positive Regulation Of Notch Signaling Pathway Response To Epidermal Growth Factor Response To Lithium Ion Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Cerebral Cortex Neuron Differentiation Adrenal Gland Development Oligodendrocyte Development Autonomic Nervous System Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter Muscle Structure Development Positive Regulation Of Protein Binding Chondrocyte Differentiation Muscle Organ Development Ossification Positive Regulation Of Transcription, DNA-templated Cell Fate Commitment Striated Muscle Tissue Development Positive Regulation Of Neuron Differentiation Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Binding Positive Regulation Of Cellular Biosynthetic Process Cardiovascular System Development Regulation Of Striated Muscle Tissue Development Positive Regulation Of Neurogenesis Skeletal Muscle Tissue Development Osteoblast Differentiation Positive Regulation Of Phosphatase Activity Regulation Of Protein Binding Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A Skeletal Muscle Organ Development Heart Valve Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Heart Valve Development Organ Morphogenesis Positive Regulation Of Cell Development Positive Regulation Of Bone Mineralization Heart Development Endochondral Ossification Positive Regulation Of Biomineral Tissue Development Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Muscle Cell Fate Determination Cartilage Development Regulation Of Neuron Differentiation Neuroepithelial Cell Differentiation Positive Regulation Of Dephosphorylation Positive Regulation Of Cell Proliferation In Bone Marrow Bone Development Nervous System Development Connective Tissue Development Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Behavioral Fear Response
Tagcloud ?		adjacent aims apc behavior cd44 cervical clones detect indicators lymph metastasis microarray microsphere microspheres myc myst2 nod node oct prognostic regulators renewal scid select sox1 stabilize suspension technology tumorigenicity	axons chick circuitry commissure confirms cumulate describing differentiating follower gives highlighting hypothalamic hypothalamus mammillotegmental neglected neurogenesis nmtt notch ntpoc patterning postoptic proneural prosencephalon spatially temporally tracts ventral vertebrate vlt
Tagcloud (Difference) ?		adjacent aims apc behavior cd44 cervical clones detect indicators lymph metastasis microarray microsphere microspheres myc myst2 nod node oct prognostic regulators renewal scid select sox1 stabilize suspension technology tumorigenicity	axons chick circuitry commissure confirms cumulate describing differentiating follower gives highlighting hypothalamic hypothalamus mammillotegmental neglected neurogenesis nmtt notch ntpoc patterning postoptic proneural prosencephalon spatially temporally tracts ventral vertebrate vlt
Tagcloud (Intersection) ?