DEFA1 and DEFA3

Number of citations of the paper that reports this interaction (PubMedID 2997278)
46

Data Source:
HPRD (in vitro)

		DEFA1	DEFA3
Description		defensin alpha 1	defensin alpha 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Pore-forming Activity	Protein Homodimerization Activity Pore-forming Activity
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response T Cell Chemotaxis Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Innate Immune Response In Mucosa Defense Response Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Defensins Alpha-defensins Neutrophil degranulation	Defensins Alpha-defensins
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Dental caries (decayed and filled deciduous teeth) ( 31533690) Monocyte percentage of white cells ( 32888494)
Interacting Genes		7 interacting genes: ACE2 C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2	1 interacting genes: DEFA1
Entrez ID		1667	1668
HPRD ID		00499	05159
Ensembl ID		ENSG00000206047	ENSG00000239839
Uniprot IDs		P59665	P59666 Q6EZE9
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF	1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Systemic Arterial Blood Pressure Complement Component C1q Complex IgM Binding Complement Component C1 Complex Cell Surface Blood Microparticle Disruption Of Plasma Membrane Integrity In Another Organism Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Superior Temporal Gyrus Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Proteolysis Regulation Of Protein Metabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of TORC2 Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Protease Binding Regulation Of Glycogen (starch) Synthase Activity Viral Process Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance Regulation Of Blood Pressure Regulation Of Tube Size Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Viral Translation Viral Life Cycle Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Tryptophan Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Cilium Positive Regulation Of Gap Junction Assembly Pore-forming Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome	Disruption Of Plasma Membrane Integrity In Another Organism Pore-forming Activity Biological Process Involved In Interaction With Symbiont Lymphocyte Chemotaxis Mucosal Immune Response Defense Response To Protozoan T Cell Migration Killing By Host Of Symbiont Cells Innate Immune Response In Mucosa T Cell Chemotaxis Estrogen Receptor Signaling Pathway Response To Protozoan Organ Or Tissue Specific Immune Response Lymphocyte Migration Defense Response To Fungus Response To Fungus Antibacterial Humoral Response Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Defense Response To Gram-negative Bacterium Azurophil Granule Lumen Golgi Lumen Nuclear Receptor-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Mononuclear Cell Migration Defense Response To Gram-positive Bacterium Leukocyte Chemotaxis Hormone-mediated Signaling Pathway Antimicrobial Humoral Response Cell Killing Cell Chemotaxis Intracellular Receptor Signaling Pathway Leukocyte Migration Humoral Immune Response Defense Response To Virus Defense Response To Bacterium Chemotaxis Locomotion Response To Virus Response To Bacterium
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