DEFA1 and C1QB

Number of citations of the paper that reports this interaction (PubMedID 9444979)
0

Data Source:
HPRD (in vitro)

		DEFA1	C1QB
Description		defensin alpha 1	complement C1q B chain
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Symbiont Cell Surface
	Molecular Function	Protein Binding Pore-forming Activity	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response T Cell Chemotaxis Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Immune System Process Complement Activation Complement Activation, Classical Pathway Innate Immune Response Synapse Pruning
Pathways		Defensins Alpha-defensins Neutrophil degranulation	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)
Interacting Genes		7 interacting genes: ACE2 C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2	11 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA UBQLN2
Entrez ID		1667	713
HPRD ID		00499	00394
Ensembl ID		ENSG00000206047	ENSG00000173369
Uniprot IDs		P59665	A0A024RAB9 D6R934 P02746
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Systemic Arterial Blood Pressure Complement Component C1q Complex IgM Binding Complement Component C1 Complex Cell Surface Blood Microparticle Disruption Of Plasma Membrane Integrity In Another Organism Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Superior Temporal Gyrus Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Proteolysis Regulation Of Protein Metabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of TORC2 Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Protease Binding Regulation Of Glycogen (starch) Synthase Activity Viral Process Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance Regulation Of Blood Pressure Regulation Of Tube Size Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Viral Translation Viral Life Cycle Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Tryptophan Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Cilium Positive Regulation Of Gap Junction Assembly Pore-forming Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome	Complement Component C1 Complex Immune Response Defense Response To Other Organism Defense Response To Symbiont Defense Response Symbiont Cell Surface Humoral Immune Response Complement Component C1q Complex Response To Other Organism Innate Immune Response Complement Activation, Classical Pathway Extrinsic Component Of Presynaptic Membrane Immune System Process IgM Binding Response To External Biotic Stimulus Complement Activation Extracellular Region Response To Fungus Response To Stress Extrinsic Component Of Postsynaptic Membrane Synapse Pruning IgG Binding Positive Regulation Of Immune Response Opsonization Blood Microparticle Killing Of Cells Of Another Organism Immune Effector Process Activation Of Immune Response Extracellular Matrix Extracellular Space Positive Regulation Of Focal Adhesion Assembly Killing By Host Of Symbiont Cells Regulation Of Immune Response Cell Killing Positive Regulation Of Immune System Process Biological Process Involved In Interaction With Symbiont Cell Surface Defense Response To Fungus Phosphatidylserine Binding Skeletal Muscle Hypertrophy Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Collagen Trimer Negative Regulation Of Viral Process Regulation Of Cell-substrate Junction Organization Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding NF-kappaB P50/p65 Complex Positive Regulation Of Type III Interferon Production
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