PER3 and ARNTL

Number of citations of the paper that reports this interaction (PMID 14701732)
33

Data Source:
HPRD (in vivo)

		PER3	ARNTL
Gene Name		period circadian clock 3	aryl hydrocarbon receptor nuclear translocator-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Transcription Factor Complex PML Body Chromatoid Body
	Molecular Function	Signal Transducer Activity Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Aryl Hydrocarbon Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Circadian Regulation Of Gene Expression Regulation Of Circadian Sleep/wake Cycle, Sleep	Protein Import Into Nucleus, Translocation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS			Menarche (age at onset) ( 21102462) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Schizophrenia ( 23358160)
Protein-Protein Interactions		9 interactors: ARNTL CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1	20 interactors: AHR BHLHE40 CLOCK CRY1 CSNK1E EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RXRA SIRT1 SUMO2 SUMO3 UBE2I
Entrez ID		8863	406
HPRD ID		09138	03973
Ensembl ID		ENSG00000049246	ENSG00000133794
Uniprot IDs		A2I2N5 P56645	O00327
PDB IDs			4H10
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Photoperiodism Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Hair Cycle Entrainment Of Circadian Clock Blue Light Signaling Pathway Regulation Of Signal Transduction Response To Blue Light Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Circadian Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Hormone Secretion Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Signaling Cell Communication RNA Biosynthetic Process Response To Light Stimulus Regulation Of Type B Pancreatic Cell Development Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Cellular Response To Stimulus Protein-chromophore Linkage Response To Radiation Cellular Response To Radiation Positive Regulation Of Wnt Signaling Pathway RNA Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process	Rhythmic Process Circadian Regulation Of Gene Expression Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peptidyl-lysine Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Peptidyl-amino Acid Modification Signal Transduction Protein Sumoylation Regulation Of Cellular Process Regulation Of Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Photoperiodism Cellular Response To Hypoxia Response To Abiotic Stimulus
Tagcloud ?		aanat2 bmal1 bmal1b circadian clock cry1aa cry1ba cry1bb dark darkness dd enhances erbalpha hour implicating ld locomotor nuclease orphan per1b per2 period2 represses rev roralpha rore talen vertebrate zebrafish	244k agilent bisulfite chemosensitivity chip circadian clock cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Difference) ?		aanat2 bmal1 bmal1b cry1aa cry1ba cry1bb dark darkness dd enhances erbalpha hour implicating ld locomotor nuclease orphan per1b per2 period2 represses rev roralpha rore talen vertebrate zebrafish	244k agilent bisulfite chemosensitivity chip cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Intersection) ?		circadian clock