PER3

Description		period circadian regulator 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Regulation Of Circadian Sleep/wake Cycle, Sleep Rhythmic Process Protein Stabilization
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Ulcerative colitis ( 28067908)
Interacting Genes		9 interacting genes: BMAL1 CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1
Entrez ID		8863
HPRD ID		09138
Ensembl ID		ENSG00000049246
Uniprot IDs		A0A087WV69 A2I2N5 P56645
PDB IDs
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Photoperiodism Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock E-box Binding Negative Regulation Of Circadian Rhythm Regulation Of Hormone Secretion Transcription Cis-regulatory Region Binding Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Light Stimulus Regulation Of Hair Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Cry-Per Complex Response To Radiation Negative Regulation Of Glucocorticoid Secretion CLOCK-BMAL Transcription Complex Regulation Of Hormone Levels Response To Blue Light Regulation Of Secretion By Cell Regulation Of Signal Transduction Regulation Of Secretion Regulation Of Type B Pancreatic Cell Development Regulation Of Gene Expression Photoreceptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Kinase Binding Positive Regulation Of Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Chromatoid Body Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Response To Redox State Positive Regulation Of Protein Metabolic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Cell Communication
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