RNF19A and C11orf58

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RNF19A	C11orf58
Description		ring finger protein 19A, RBR E3 ubiquitin protein ligase	chromosome 11 open reading frame 58
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Centrosome Cytosol Cytoskeleton Membrane	Cellular_component
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Molecular_function
	Biological Process	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Biological_process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Atrioventricular conduction ( 21041692) Recurrent major depressive disorder ( 29317602)	Chronotype ( 30696823) Coronary artery disease ( 33020668) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lumbar spine bone mineral density ( 29499414) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		17 interacting genes: C11orf58 CASR ILK MAP3K20 MAP3K7 NUDT21 RPS6KA5 SNCAIP SOD1 SUFU TUBG1 TUBG2 UBE2D2 UBE2E2 UBE2L3 UBE2L6 VCP	17 interacting genes: A2M CEBPA CEP126 EEF1G FBN3 MBTPS1 POLR2C PTN RNF19A RPLP1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP TRA2A ZBTB48
Entrez ID		25897	10944
HPRD ID		06176	18069
Ensembl ID		ENSG00000034677	ENSG00000110696
Uniprot IDs		Q9NV58	O00193
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleotide Binding Microtubule Nucleator Activity Mitotic Spindle Organization ISG15 Transferase Activity Microtubule Cytoskeleton Organization Involved In Mitosis ISG15-protein Conjugation Spindle Organization ATP Binding JNK Cascade Magnesium Ion Binding Gamma-tubulin Ring Complex Gamma-tubulin Complex Protein Modification Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Nucleus Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Stress-activated MAPK Cascade MAP Kinase Kinase Kinase Activity Meiotic Spindle Organization Pericentriolar Material Cytoskeleton Organization Protein Ubiquitination P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Interleukin-1-mediated Signaling Pathway Chromosome Segregation Proteolysis Involved In Protein Catabolic Process Microtubule Nucleation Protein Exit From Endoplasmic Reticulum Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Negative Regulation Of Smoothened Signaling Pathway Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Protein K11-linked Ubiquitination Protein Kinase Binding Identical Protein Binding Microtubule Cytoskeleton Organization Microtubule-based Process Transferase Activity Spindle Microtubule Flavin Adenine Dinucleotide Catabolic Process Histone H2AS1 Kinase Activity
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