MLNR and GHRHR

Number of citations of the paper that reports this interaction (PubMedID 12606621)
0

Data Source:
HPRD (in vivo)

		MLNR	GHRHR
Description		motilin receptor	growth hormone releasing hormone receptor
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Membrane Nuclear Matrix Secretory Granule Sarcolemma
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Hormone Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Lactation Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Adenohypophysis Development Growth Hormone Secretion Mammary Gland Development Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Hormone Secretion Positive Regulation Of Hormone Secretion Cell Maturation Regulation Of Protein Metabolic Process Response To Glucocorticoid Establishment Of Localization In Cell Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development Cellular Response To Glucose Stimulus CAMP/PKA Signal Transduction
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Erythromycin Mitemcinal	Sermorelin Tesamorelin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Triglyceride levels ( 34074324)
Interacting Genes		4 interacting genes: GHRHR GHRL GPRASP1 MLN	3 interacting genes: GHRH GHRL MLNR
Entrez ID		2862	2692
HPRD ID		04197	00748
Ensembl ID		ENSG00000102539	ENSG00000106128
Uniprot IDs		O43193	A0A090N8Y6 Q02643
PDB IDs		8IBU 8IBV	2XDG 7CZ5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Growth Hormone Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Behavior Positive Regulation Of Multicellular Organism Growth Response To Estrogen Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Hormone Secretion Hormone Transport Positive Regulation Of Peptide Hormone Secretion Regulation Of Circadian Rhythm Positive Regulation Of Peptide Secretion Somatotropin Secreting Cell Development Peptide Transport Hormone Activity Motilin Receptor Binding Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Amide Transport Positive Regulation Of Hormone Secretion G Protein-coupled Receptor Catabolic Process Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Signal Release Positive Regulation Of Developmental Growth Growth Hormone-releasing Hormone Receptor Activity Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Neuronal Dense Core Vesicle Lumen	Growth Hormone-releasing Hormone Activity Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Behavior Positive Regulation Of Multicellular Organism Growth Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Hormone Secretion G Protein-coupled Receptor Signaling Pathway Peptide Transport Hormone Transport Positive Regulation Of Peptide Hormone Secretion Regulation Of Circadian Rhythm Positive Regulation Of Peptide Secretion Hormone Activity Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Growth Hormone-releasing Hormone Receptor Binding Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Amide Transport Positive Regulation Of Hormone Secretion Signal Release Positive Regulation Of Developmental Growth Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Regulation Of Peptide Hormone Secretion Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Secretion By Cell Neuronal Dense Core Vesicle Lumen
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