CXCL13 and CXCR5

Number of citations of the paper that reports this interaction (PMID 9486651)
119

Data Source:
HPRD (in vitro, in vivo)

		CXCL13	CXCR5
Gene Name		chemokine (C-X-C motif) ligand 13	chemokine (C-X-C motif) receptor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Chemokine Activity Heparin Binding Fibroblast Growth Factor Binding CXCR5 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Protein Heterodimerization Activity Receptor Agonist Activity CXCR3 Chemokine Receptor Binding	G-protein Coupled Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity
	Biological Process	Germinal Center Formation Lymphocyte Chemotaxis Across High Endothelial Venule Chronic Inflammatory Response Regulation Of Humoral Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of T Cell Chemotaxis Response To Lipopolysaccharide Activation Of Rap GTPase Activity Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Chemotaxis Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Regulation Of Cell Proliferation Defense Response To Bacterium Regulation Of Angiogenesis Lymph Node Development Chemokine-mediated Signaling Pathway Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Movement Of Cell Or Subcellular Component Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143)	Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Primary biliary cirrhosis ( 21399635) Vitiligo ( 22951725)
Protein-Protein Interactions		8 interactors: ACKR4 CCL19 CCL21 CCR10 CXCR3 CXCR5 EEF1G FGF2	1 interactors: CXCL13
Entrez ID		10563	643
HPRD ID		05513	03367
Ensembl ID		ENSG00000156234
Uniprot IDs		O43927 Q53X90	A0N0R2 A8K647 P32302 Q2YD84
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cytosolic Calcium Ion Homeostasis Chemokine-mediated Signaling Pathway Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Metal Ion Homeostasis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Regulation Of Behavior Regulation Of Dendritic Cell Dendrite Assembly Cellular Chemical Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Ion Homeostasis Immune System Process Regulation Of Phosphatidylinositol 3-kinase Activity Immune Response Regulation Of Lipid Kinase Activity Cellular Homeostasis Response To Organic Substance Establishment Of T Cell Polarity Positive Regulation Of Locomotion Chemical Homeostasis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Leukocyte Chemotaxis Regulation Of Leukocyte Migration Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Immunological Synapse Formation Leukocyte Activation Positive Regulation Of Glycoprotein Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Prostaglandin E Cell Chemotaxis Cellular Response To Cytokine Stimulus Regulation Of Cell Migration	Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Chemotaxis Across High Endothelial Venule Activation Of Rap GTPase Activity B Cell Chemotaxis Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Integrin Activation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Chemotaxis Regulation Of Integrin Activation Chronic Inflammatory Response Endothelial Cell Chemotaxis Germinal Center Formation Lymphocyte Chemotaxis Lymph Node Development Positive Regulation Of Rap GTPase Activity Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Negative Regulation Of Chemotaxis Lymphocyte Migration Regulation Of Lymphocyte Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Receptor Activity Negative Regulation Of Epithelial Cell Migration Regulation Of Humoral Immune Response Activation Of Ras GTPase Activity Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Endothelial Cell Migration Positive Regulation Of Leukocyte Migration Epithelial Cell Migration Epithelium Migration Leukocyte Chemotaxis Regulation Of Endothelial Cell Migration Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Regulation Of Receptor Activity Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Epithelial Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Chemotaxis
Tagcloud ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	account acute alterations asthma bcl blimp cd4 circulating classified cytometry detect elisa enrolled follicular helper ige il immunological lymphocytes microenvironment mrna negatively plasma positively proportion remission sandwich sixty tfh
Tagcloud (Difference) ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	account acute alterations asthma bcl blimp cd4 circulating classified cytometry detect elisa enrolled follicular helper ige il immunological lymphocytes microenvironment mrna negatively plasma positively proportion remission sandwich sixty tfh
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