CXCL13 and CXCR5

Number of citations: 33 (PubMedID 9463416)
Data Source: HPRD (in vivo, in vitro)

		CXCL13	CXCR5
Name		C-X-C motif chemokine ligand 13	C-X-C motif chemokine receptor 5
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Chemokine Activity Heparin Binding Fibroblast Growth Factor Binding CXCR5 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding	G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Germinal Center Formation Lymphocyte Chemotaxis Across High Endothelial Venule Chronic Inflammatory Response Regulation Of Humoral Immune Response Chemotaxis Defense Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Killing Of Cells Of Another Organism Regulation Of Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Chemotaxis Endothelial Cell Chemotaxis To Fibroblast Growth Factor Defense Response To Bacterium Regulation Of Angiogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
GWAS		Cardiac Troponin-T levels ( 23247143 ) Diffusing capacity of carbon monoxide ( 30694715 ) Rheumatoid arthritis ( 32723749 ) Tonsillectomy ( 27182965 28928442 ) Waist circumference adjusted for body mass index ( 28552196 )	Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Follicular lymphoma ( 25279986 ) Human herpes virus 7 U14 antibody levels ( 33204752 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 24076602 ) Post-bronchodilator lung function in asthma (FVC) ( 32989782 ) Primary biliary cholangitis ( 21399635 26394269 28425483 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30423114 24390342 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 32771030 ) Trunk fat mass ( 28552196 ) Vitiligo ( 22951725 )
Interacting Genes		11 interacting genes: ACKR4 CCL19 CCL21 CCL28 CCL4L1 CCR10 CXCR3 CXCR5 EEF1G FGF2 PF4V1	1 interacting genes: CXCL13
Entrez ID		10563	643
HPRD ID		05513	03367
Ensembl ID		ENSG00000156234	ENSG00000160683
Uniprot IDs		O43927 Q53X90	A0N0R2 A8K647 P32302 Q2YD84
PDB IDs		5CBA 5CBE 6VGJ 7JNY	Not available
GO Terms Enriched among Interactors		Chemotaxis Locomotion Cell Chemotaxis Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Cell Migration Cell Motility Leukocyte Migration Chemokine Activity Granulocyte Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Cytokine-mediated Signaling Pathway Cytokine Activity Granulocyte Migration Immune Response Chemokine Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine Receptor Binding Antimicrobial Humoral Response Immune System Process G Protein-coupled Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Humoral Immune Response Chemokine Receptor Activity Inflammatory Response CCR7 Chemokine Receptor Binding CCR Chemokine Receptor Binding Regulation Of Sequestering Of Calcium Ion Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Calcium-mediated Signaling Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Cell Surface Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Chemotaxis Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of Leukocyte Migration C-X-C Chemokine Receptor Activity Establishment Of T Cell Polarity Negative Regulation Of Cellular Extravasation Regulation Of Cell Migration Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Cell Motility	Regulation Of Rap Protein Signal Transduction UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Mitochondrial Double-strand Break Repair Via Homologous Recombination Structural Constituent Of Presynaptic Actin Cytoskeleton CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Cerebellar Purkinje Cell Layer Maturation UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor CCR10 Chemokine Receptor Binding Ubiquitin-dependent Endocytosis Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Meiotic DNA Double-strand Break Formation Mre11 Complex BRCA1-C Complex Chromosomal Region Telomeric 3' Overhang Formation Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CXCR3 Chemokine Receptor Binding Negative Regulation Of Endothelial Cell Chemotaxis B Cell Chemotaxis DNA Damage Response Regulation Of Mitotic Recombination Presynaptic Cytoskeleton Organization Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor