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RAB14 and SMURF2
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
RAB14
SMURF2
Description
RAB14, member RAS oncogene family
SMAD specific E3 ubiquitin protein ligase 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Lysosome
Lysosomal Membrane
Endosome
Early Endosome
Late Endosome
Rough Endoplasmic Reticulum
Golgi Apparatus
Golgi Stack
Trans-Golgi Network
Cytosol
Plasma Membrane
Cilium
Endomembrane System
Membrane
Trans-Golgi Network Transport Vesicle
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Recycling Endosome
Recycling Endosome Membrane
Extracellular Exosome
Tertiary Granule Membrane
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Nuclear Speck
Membrane Raft
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Myosin V Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Identical Protein Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
Biological Process
Phagolysosome Assembly
Intracellular Protein Transport
Golgi To Endosome Transport
Fibroblast Growth Factor Receptor Signaling Pathway
Protein Transport
Vesicle-mediated Transport
Endocytic Recycling
Regulation Of Protein Localization
Endosomal Vesicle Fusion
Early Endosome To Golgi Transport
Defense Response To Bacterium
Regulation Of Embryonic Development
Intracellular Transport
Phagosome Maturation
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Trophoblast Cell Migration
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Synthesis of PIPs at the plasma membrane
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Asymmetric localization of PCP proteins
Degradation of AXIN
Hedgehog 'on' state
Hedgehog 'on' state
Ub-specific processing proteases
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Cardiac troponin-I levels (
31014085
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Joint mobility (Beighton score) (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Periodontitis (Mean PAL) (
24024966
)
Interacting Genes
13 interacting genes:
ADRB2
APP
ARL8B
CHM
EXOC5
GARIN6
OCRL
OPTN
RAB11FIP5
RBSN
RUFY1
SH3BP5L
SMURF2
94 interacting genes:
ABRAXAS2
ACBD3
ACOX3
ADAR
AIMP2
ANAPC5
ARHGAP5
ASH2L
AXIN1
BTRC
CANX
CNKSR2
CUEDC1
DAB2
DAZAP2
DGCR2
DSCR9
EGFR
EPHA1
ERBB2
FKBP4
FLNB
FUBP1
GNG2
HDGFL3
ING2
IRF3
IRF8
ITGB1BP1
KLF5
LAPTM5
LATS1
LITATS1
LMNA
MAVS
NEK6
NKIRAS1
NRAS
PARP1
PDE4B
PPID
PRICKLE1
PRICKLE2
RAB13
RAB14
RAB17
RAB22A
RAB25
RAN
RAP1B
RASD2
RASL12
RHOD
RLIM
RNF11
RNF111
RNF2
RPS27A
RRAS2
RTN4IP1
RUNX2
RUNX3
SF3A2
SKIL
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SMAP1
SNCA
SNRNP70
SOCS6
SPART
SRSF4
TFPI2
TGFBR1
TMEM139
TNPO3
TOP2A
TRAF2
TRAF4
TRIM28
TSSK4
TXNIP
UBC
UBE2D2
UBE2D3
UBE2L3
USP15
XPO1
YY1
ZBTB44
Entrez ID
51552
64750
HPRD ID
06693
06901
Ensembl ID
ENSG00000119396
ENSG00000108854
Uniprot IDs
P61106
Q96DE7
Q9HAU4
PDB IDs
1Z0F
4D0G
4DRZ
1ZVD
2DJY
2JQZ
2KXQ
2LTZ
6FX4
7M3Q
Enriched GO Terms of Interacting Partners
?
Vesicle-mediated Transport
Endosome
Early Endosome Membrane
Early Endosome To Golgi Transport
Early Endosome
Small GTPase Binding
Golgi Vesicle Transport
Cellular Response To Amyloid-beta
Response To Amyloid-beta
Innate Immune Response
Response To Mechanical Stimulus
Positive Regulation Of CAMP/PKA Signal Transduction
Golgi-associated Vesicle
Defense Response To Symbiont
Defense Response To Gram-negative Bacterium
Protein Transport
Endosomal Vesicle Fusion
Cellular Localization
Defense Response To Other Organism
Retrograde Transport, Endosome To Golgi
Platelet Alpha Granule
Post-Golgi Vesicle-mediated Transport
Neuronal Dense Core Vesicle
Defense Response To Bacterium
Lysosomal Transport
Establishment Of Protein Localization
Cytosolic Transport
Recycling Endosome
Amyloid Fibril Formation
Ionotropic Glutamate Receptor Signaling Pathway
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine
Ligand-gated Ion Channel Signaling Pathway
Vacuolar Transport
Negative Regulation Of Cell Communication
Positive Regulation Of Mini Excitatory Postsynaptic Potential
Negative Regulation Of Signaling
Amyloid-beta Complex
Regulation Of Extrinsic Apoptotic Signaling Pathway
Growth Cone Lamellipodium
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Response To Calcium Ion
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Response To Bacterium
Positive Regulation Of Nitric Oxide Metabolic Process
Negative Regulation Of Blood Coagulation, Common Pathway
Membrane Organization
Regulation Of Plasma Membrane Raft Polarization
Phosphatidylinositol 3-kinase Catalytic Subunit Binding
Ubiquitin Protein Ligase Binding
I-SMAD Binding
Heteromeric SMAD Protein Complex
Response To Growth Factor
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Protein Signal Transduction
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Binding
Enzyme-linked Receptor Protein Signaling Pathway
Protein-containing Complex
Negative Regulation Of RNA Metabolic Process
GTPase Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
GDP Binding
Negative Regulation Of Transcription By RNA Polymerase II
GTP Binding
Nucleoplasm
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Cytosol
Negative Regulation Of Signal Transduction
SMAD Protein Complex
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Cell Development
Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Transcription Regulator Complex
Ureteric Bud Development
Negative Regulation Of Macromolecule Metabolic Process
Post-translational Protein Modification
Response To Transforming Growth Factor Beta
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Osteoblast Fate Commitment
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Mesonephric Tubule Development
Cellular Developmental Process
Intracellular Signal Transduction
Mesonephric Epithelium Development
Positive Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
R-SMAD Binding
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