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ISYNA1 and PPP2CA
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ISYNA1
PPP2CA
Gene Name
inositol-3-phosphate synthase 1
protein phosphatase 2, catalytic subunit, alpha isozyme
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Extracellular Vesicular Exosome
Molecular Function
Inositol-3-phosphate Synthase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Protein Dimerization Activity
GABA Receptor Binding
Biological Process
Inositol Biosynthetic Process
Phospholipid Biosynthetic Process
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Mitotic Cell Cycle
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Mitotic Nuclear Envelope Reassembly
Mesoderm Development
RNA Splicing
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Organic Substance
Gene Expression
Regulation Of Receptor Activity
Negative Regulation Of Epithelial To Mesenchymal Transition
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Regulation Of Protein Autophosphorylation
Regulation Of Growth
Regulation Of Protein Catabolic Process
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Protein Heterotrimerization
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Synthesis of IP2, IP, and Ins in the cytosol
Inositol phosphate metabolism
Signaling by GPCR
Integration of energy metabolism
Signaling by FGFR in disease
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Initiation of Nuclear Envelope Reformation
Mitotic G1-G1/S phases
ERK/MAPK targets
Negative regulation of FGFR signaling
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Spry regulation of FGF signaling
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
M Phase
Toll Like Receptor TLR6:TLR2 Cascade
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Nuclear Envelope Reassembly
Innate Immune System
Nonsense-Mediated Decay (NMD)
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Signaling by FGFR
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Breast cancer (
23535729
)
Protein-Protein Interactions
4 interactors:
DUSP14
POT1
PPP2CA
TRAF4
71 interactors:
ADCY8
AKT1
APC
AXIN1
BCL2
BEST1
BMPR1B
CAD
CAV1
CCNG1
CCNG2
CDK2
CDK6
CDKN2C
CHEK2
CXCR2
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
ISYNA1
JAK2
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYH9
NME2
NXN
PACS1
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTN
PXN
RACGAP1
RBL2
RELA
RHO
RHOB
RPS6KB1
RRAS
SET
SGK1
SGOL1
SGOL2
STAT5A
STAT5B
STRN
TLX1
TP53
TRIP13
TSC2
VAC14
VDR
XRN1
Entrez ID
51477
5515
HPRD ID
17163
08912
Ensembl ID
ENSG00000105655
Uniprot IDs
Q9NPH2
B3KUN1
P67775
PDB IDs
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Transferase Activity
Inactivation Of MAPK Activity
Positive Regulation Of Transferase Activity
Regulation Of MAPK Cascade
Negative Regulation Of MAP Kinase Activity
Regulation Of Catalytic Activity
Regulation Of Protein Kinase Activity
Negative Regulation Of Catalytic Activity
Regulation Of Kinase Activity
Positive Regulation Of DNA Strand Elongation
Regulation Of DNA Replication
Negative Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of MAPK Cascade
Regulation Of Protein Phosphorylation
Telomere Formation Via Telomerase
Negative Regulation Of Protein Kinase Activity
Negative Regulation Of Kinase Activity
Regulation Of Phosphorylation
Protein Dephosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Regulation Of MAP Kinase Activity
Positive Regulation Of Helicase Activity
Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Catalytic Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Telomerase Activity
Telomere Assembly
Positive Regulation Of Telomere Maintenance Via Telomerase
Mitotic Nuclear Envelope Reassembly
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Phosphorylation
Negative Regulation Of Telomerase Activity
Positive Regulation Of Protein Homodimerization Activity
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Protein Heterotrimerization
Negative Regulation Of Intracellular Signal Transduction
Nuclear Envelope Reassembly
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Kinase Activity
Dephosphorylation
Positive Regulation Of Kinase Activity
Regulation Of Telomerase Activity
Negative Regulation Of Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Cell Cycle
Mitotic Cell Cycle
Regulation Of Catalytic Activity
Cell Cycle Process
Signal Transduction
Cellular Response To Stimulus
Regulation Of Protein Metabolic Process
Signaling
Cell Communication
Regulation Of Cell Cycle
Regulation Of Apoptotic Process
Regulation Of Cell Proliferation
Regulation Of Cell Death
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Regulation Of Phosphorylation
Response To Organonitrogen Compound
Regulation Of Phosphorus Metabolic Process
Apoptotic Process
Developmental Process
Regulation Of Metabolic Process
Response To Organic Substance
Programmed Cell Death
Mitotic Cell Cycle Process
Regulation Of Kinase Activity
Cellular Response To Organic Substance
Anatomical Structure Development
Cell Surface Receptor Signaling Pathway
Cell Death
Death
Regulation Of Cellular Protein Metabolic Process
System Development
Cellular Response To Organonitrogen Compound
Cellular Response To Peptide Hormone Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Apoptotic Process
Regulation Of Body Fluid Levels
Organ Development
Multicellular Organismal Development
Negative Regulation Of Programmed Cell Death
Cellular Response To Peptide
Response To Hormone
Regulation Of MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stress
Negative Regulation Of Cell Death
Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Tagcloud
?
bioinformatics
bmp2
calm1
cnaq
csf2rb
csf3
expressions
fifteen
gria2
il10ra
il10rb
il11ra
il3ra
il6st
lifr
lymphatic
microarrays
myl9
mylk
myosin
nonsmokers
nsclc
paraneoplastic
pathohistological
plcb4
rac3
rock2
thbs1
verify
Tagcloud (Difference)
?
bioinformatics
bmp2
calm1
cnaq
csf2rb
csf3
expressions
fifteen
gria2
il10ra
il10rb
il11ra
il3ra
il6st
lifr
lymphatic
microarrays
myl9
mylk
myosin
nonsmokers
nsclc
paraneoplastic
pathohistological
plcb4
rac3
rock2
thbs1
verify
Tagcloud (Intersection)
?