ISYNA1 and DUSP14

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ISYNA1	DUSP14
Gene Name		inositol-3-phosphate synthase 1	dual specificity phosphatase 14
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Inositol-3-phosphate Synthase Activity	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Poly(A) RNA Binding
	Biological Process	Inositol Biosynthetic Process Phospholipid Biosynthetic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Inactivation Of MAPK Activity Peptidyl-tyrosine Dephosphorylation
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS		Breast cancer ( 23535729)	Ovarian cancer ( 23535730)
Protein-Protein Interactions		4 interactors: DUSP14 POT1 PPP2CA TRAF4	4 interactors: CD28 ISYNA1 SPERT UCHL5
Entrez ID		51477	11072
HPRD ID		17163	09427
Ensembl ID		ENSG00000105655	ENSG00000161326
Uniprot IDs		Q9NPH2	O95147 Q6FI36
PDB IDs			2WGP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transferase Activity Inactivation Of MAPK Activity Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Negative Regulation Of MAP Kinase Activity Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of DNA Strand Elongation Regulation Of DNA Replication Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Telomere Formation Via Telomerase Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Phosphorylation Protein Dephosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of MAP Kinase Activity Positive Regulation Of Helicase Activity Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Mitotic Nuclear Envelope Reassembly Regulation Of Intracellular Signal Transduction Negative Regulation Of Phosphorylation Negative Regulation Of Telomerase Activity Positive Regulation Of Protein Homodimerization Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Protein Heterotrimerization Negative Regulation Of Intracellular Signal Transduction Nuclear Envelope Reassembly Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Dephosphorylation Positive Regulation Of Kinase Activity Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process	Inositol Biosynthetic Process Regulatory T Cell Differentiation Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative Thymic T Cell Selection Cellular Response To Growth Factor Stimulus Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Negative T Cell Selection Response To Growth Factor Inositol Metabolic Process Positive Regulation Of Viral Genome Replication Forebrain Morphogenesis Thymic T Cell Selection Lateral Ventricle Development Regulation Of Interleukin-2 Biosynthetic Process Cytokine Biosynthetic Process Positive Regulation Of Isotype Switching Regulation Of Defense Response To Virus By Virus Cytokine Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Isotype Switching Positive Regulation Of Interleukin-2 Production Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Mitotic Nuclear Division T Cell Selection Brain Morphogenesis Ventricular System Development Inositol Phosphate Metabolic Process
Tagcloud ?			attenuated autoimmune classified deficiency deficient dephosphorylated dual encephalomyelitis enhanced hairpin ikappab immune inactivation inhibiting interacted jnk mapks mkp6 negatively phosphatase remain responses ser susceptible tab1 tak1 tcr tgf upon
Tagcloud (Difference) ?			attenuated autoimmune classified deficiency deficient dephosphorylated dual encephalomyelitis enhanced hairpin ikappab immune inactivation inhibiting interacted jnk mapks mkp6 negatively phosphatase remain responses ser susceptible tab1 tak1 tcr tgf upon
Tagcloud (Intersection) ?