ISYNA1 and DUSP14

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ISYNA1	DUSP14
Description		inositol-3-phosphate synthase 1	dual specificity phosphatase 14
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Inositol-3-phosphate Synthase Activity Protein Binding Isomerase Activity	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Inositol Biosynthetic Process Lipid Metabolic Process Phospholipid Biosynthetic Process
Pathways		Synthesis of IP2, IP, and Ins in the cytosol
Drugs		2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate 2-Deoxy-Glucitol-6-Phosphate Glycerin
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Breast cancer ( 23535729) Heel bone mineral density ( 30598549)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Monocyte count ( 27863252 32888494) Ovarian cancer ( 23535730) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: DUSP14 GRSF1 OGT POT1 PPP2CA TRAF4	17 interacting genes: AATK CBY2 CD28 EPHA1 EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 IGF1R ISYNA1 LMTK2 PRMT5 PTK7 ROR1 ROR2 UCHL5
Entrez ID		51477	11072
HPRD ID		17163	09427
Ensembl ID		ENSG00000105655	ENSG00000276023
Uniprot IDs		A0A140VK73 Q9NPH2	O95147 Q6FI36
PDB IDs			2WGP
Enriched GO Terms of Interacting Partners?		Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Purine Nucleotide Metabolic Process Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Mitochondrial RNA Catabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Phosphoprotein Phosphatase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Chromosome Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomere Assembly Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Shelterin Complex Mitochondrial RNA Catabolic Process Regulation Of Primary Metabolic Process RNA Catabolic Process Carbon Catabolite Regulation Of Transcription Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Macromolecule Metabolic Process G-quadruplex RNA Binding DEAD/H-box RNA Helicase Binding Protein Serine/threonine Phosphatase Complex Peptidyl-threonine Dephosphorylation Regulation Of Transcription By Glucose Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Thioesterase Binding G-rich Strand Telomeric DNA Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Coreceptor Activity Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling ERBB2 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Neuregulin Receptor Activity Protein Autophosphorylation Regulation Of ERK1 And ERK2 Cascade ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Animal Organ Development Mesenchyme Development Phosphorylation ERBB2-ERBB3 Signaling Pathway Glial Cell Development ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Lung-associated Mesenchyme Development Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wound Healing ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Ephrin Receptor Activity Heart Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?