TRAPPC4 and SDC2

Number of citations of the paper that reports this interaction (PubMedID 11018053)
58

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TRAPPC4	SDC2
Description		trafficking protein particle complex subunit 4	syndecan 2
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Synaptic Vesicle Membrane TRAPP Complex Dendrite Vesicle Synapse Postsynaptic Membrane Presynaptic Active Zone Postsynaptic Density Membrane TRAPPII Protein Complex TRAPPIII Protein Complex	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen
	Molecular Function	Protein Binding	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Autophagy Vesicle-mediated Transport Dendrite Development COPII Vesicle Coating Vesicle Tethering	Nervous System Development Cell Migration Cell Differentiation Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways		COPII-mediated vesicle transport Syndecan interactions RAB GEFs exchange GTP for GDP on RABs	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs		S-palmitoyl-L-cysteine	Sargramostim
Diseases
GWAS			Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: APP PRSS23 SDC2 TFIP11 TRAPPC12 TRAPPC2 TRAPPC3L TRAPPC8	29 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4 UBC
Entrez ID		51399	6383
HPRD ID		18220	00803
Ensembl ID		ENSG00000196655	ENSG00000169439
Uniprot IDs		B4DF86 E9PKS9 E9PQE8 J3KP27 Q9Y296	E9PBI9 P34741
PDB IDs		2J3T 2JSN 2ZMV	6ITH
Enriched GO Terms of Interacting Partners?		TRAPP Complex TRAPPIII Protein Complex COPII Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Tethering Vesicle Coating Golgi Vesicle Transport Intracellular Transport Vesicle-mediated Transport Protein-containing Complex Organization Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Lumen Vesicle Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum-Golgi Intermediate Compartment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Golgi Lumen Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Organization Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Regulation Of Kinetochore Assembly Positive Regulation Of Protein Localization To Kinetochore Protein-containing Complex Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Golgi Apparatus Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon	Extracellular Space Regulation Of Multicellular Organismal Process Platelet Alpha Granule Lumen Extracellular Region Regulation Of Developmental Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of MAPK Cascade Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Heparin Binding Signaling Receptor Binding Positive Regulation Of Gene Expression Extracellular Matrix Regulation Of Response To Wounding Basement Membrane Signal Transduction Regulation Of Endothelial Cell Migration Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Vasculature Development Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Anatomical Structure Morphogenesis Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Regulation Of Vesicle-mediated Transport Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Signal Transduction
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