TRAPPC4 and TRAPPC2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		TRAPPC4	TRAPPC2
Description		trafficking protein particle complex subunit 4	trafficking protein particle complex subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Synaptic Vesicle Membrane TRAPP Complex Dendrite Vesicle Synapse Postsynaptic Membrane Presynaptic Active Zone Postsynaptic Density Membrane TRAPPII Protein Complex TRAPPIII Protein Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Protein Binding	Protein Binding Transmembrane Transporter Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Autophagy Vesicle-mediated Transport Dendrite Development COPII Vesicle Coating Vesicle Tethering	Skeletal System Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport COPII Vesicle Coating Vesicle Tethering
Pathways		COPII-mediated vesicle transport Syndecan interactions RAB GEFs exchange GTP for GDP on RABs	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs		S-palmitoyl-L-cysteine
Diseases			Spondyloepiphyseal dysplasia tarda
GWAS
Interacting Genes		8 interacting genes: APP PRSS23 SDC2 TFIP11 TRAPPC12 TRAPPC2 TRAPPC3L TRAPPC8	34 interacting genes: ABRA CLIC1 CLIC2 DAPK1 EIF3C ENO1 ENO3 EPS15L1 HLA-E INCA1 KCTD1 MBD3L1 MFHAS1 NICN1 NME4 NR5A1 PITX1 PYGM REPS1 SLC25A35 SNAPC5 SNCA TEPSIN TRAPPC3 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9 UQCC2 ZBTB38 ZNF438 ZNF655 ZRANB1
Entrez ID		51399	6399
HPRD ID		18220	02189
Ensembl ID		ENSG00000196655	ENSG00000196459
Uniprot IDs		B4DF86 E9PKS9 E9PQE8 J3KP27 Q9Y296	P0DI81 P0DI82 Q6IBE5
PDB IDs		2J3T 2JSN 2ZMV
Enriched GO Terms of Interacting Partners?		TRAPP Complex TRAPPIII Protein Complex COPII Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Tethering Vesicle Coating Golgi Vesicle Transport Intracellular Transport Vesicle-mediated Transport Protein-containing Complex Organization Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Lumen Vesicle Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum-Golgi Intermediate Compartment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Golgi Lumen Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Organization Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Regulation Of Kinetochore Assembly Positive Regulation Of Protein Localization To Kinetochore Protein-containing Complex Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Golgi Apparatus Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon	TRAPP Complex Vesicle Tethering TRAPPII Protein Complex Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity COPII Vesicle Coating Golgi Vesicle Transport Protein Binding Cis-Golgi Network Membrane Vesicle-mediated Transport Vesicle Organization Intracellular Transport Establishment Of Localization In Cell
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