TBC1D21 and RAB3IP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D21	RAB3IP
Description		TBC1 domain family member 21	RAB3A interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoskeleton Cytoplasmic Vesicle Extracellular Exosome Sperm Midpiece	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Vesicle Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Proximal Dendrite
	Molecular Function	Actin Binding GTPase Activator Activity Protein Binding Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding GTPase Binding
	Biological Process	Spermatogenesis Sperm Axoneme Assembly Cell Differentiation Flagellated Sperm Motility Plasma Membrane To Endosome Transport Sperm Mitochondrial Sheath Assembly Regulation Of Cilium Assembly	Protein Targeting To Membrane Golgi To Plasma Membrane Transport Protein Transport Negative Regulation Of Filopodium Assembly Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways			Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium BBSome-mediated cargo-targeting to cilium RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Coffee consumption (cups per day) ( 31837886) Estimated glomerular filtration rate ( 31152163) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Feeling fed-up ( 29500382) Glucose homeostasis traits ( 25524916) LDL cholesterol levels in HIV infection ( 33109212)	Diastolic blood pressure ( 27841878) Height ( 28552196) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		29 interacting genes: APP CCDC158 CFAP53 EVI5L GAS2 GFAP GTF2E1 KIF26A KRT15 KRT35 KRT37 KRT38 KRT40 LCN2 MEOX2 NR1D2 NUTM1 PDCD2 PMF1 PMF1-BGLAP RAB3IP REL RIBC1 SAMD4A SEPTIN2 SNX7 STMN3 TCF12 TIMM10	32 interacting genes: BANP CCDC196 CHCHD3 DNAJB13 FAM124A KRT40 MB21D2 MBD3 MVP NAA10 PEG10 PKN1 PLOD3 PPL PRKAB2 RAB11A RAB3A RAB3D RAB3IL1 RAB8A RAB8B RUFY1 SFN SSX2 SUV39H2 TBC1D21 TEPSIN TRAPPC6A TXNDC5 ZBTB16 ZNF410 ZNF76
Entrez ID		161514	117177
HPRD ID		15473	10565
Ensembl ID		ENSG00000167139	ENSG00000127328
Uniprot IDs		Q8IYX1	Q96QF0
PDB IDs			4LHX 4LHY 4LHZ 4UJ3 4UJ4 4UJ5 6F6P
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Keratin Filament Cytoskeleton Structural Molecule Activity Regulation Of Cell Projection Organization Astrocyte Projection Morphogenesis Of An Epithelium Negative Regulation Of Cell Projection Organization Regulation Of Neurotransmitter Uptake Epithelial Cell Differentiation Tissue Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonemal A Tubule Inner Sheath	Myosin V Binding Protein Transport Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Exocytosis Plasma Membrane To Endosome Transport Intracellular Protein Localization Vesicle Organization GTPase Activity Vesicle-mediated Transport Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Endocytic Recycling Trans-Golgi Network Transport Vesicle Endosome Establishment Of Protein Localization Phagocytic Vesicle GTP Binding Vesicle-mediated Transport In Synapse GTP-dependent Protein Binding Secretion By Cell Cytoplasmic Vesicle Recycling Endosome Membrane Extracellular Exosome Regulation Of Long-term Neuronal Synaptic Plasticity Trans-Golgi Network Membrane Organelle Organization Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Endosomal Transport Regulation Of Presynaptic Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Synaptic Vesicle Endosomal Processing Coated Vesicle Membrane Organelle Fusion
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