NINJ1 and CEACAM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NINJ1	CEACAM3
Description		ninjurin 1	CEA cell adhesion molecule 3
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Synapse Synaptic Membrane	Plasma Membrane Cell Surface Membrane Specific Granule Membrane
	Molecular Function	Lipopolysaccharide Binding Protein Binding Cell Adhesion Mediator Activity Membrane Destabilizing Activity	Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Angiogenesis Leukocyte Chemotaxis Involved In Inflammatory Response Inflammatory Response Cell Adhesion Nervous System Development Cytolysis Killing Of Cells Of Another Organism Heterotypic Cell-cell Adhesion Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Tissue Regeneration Muscle Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Inflammatory Response Protein Homooligomerization Cellular Hyperosmotic Response Regulation Of Monocyte Chemotaxis Programmed Necrotic Cell Death Ferroptosis Pyroptotic Cell Death	Regulation Of Immune System Process Signal Transduction
Pathways			Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Lactate dehydrogenase levels ( 29403010) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity (early onset extreme) ( 23563609)
Interacting Genes		21 interacting genes: AQP6 ATP6AP2 CD200R1 CEACAM3 CREB3L1 CYB5R3 EBP FCGR1A FNDC9 GOLM1 GPX8 HIVEP1 KRT40 LIME1 MUC1 PVR SGCB TIMMDC1 TLCD4 TMEM14B TMEM31	8 interacting genes: CEACAM1 CNIH3 CSNK1A1L NINJ1 NINJ2 PMP22 S100A8 SRC
Entrez ID		4814	1084
HPRD ID		03639	16450
Ensembl ID		ENSG00000131669	ENSG00000170956
Uniprot IDs		Q92982	P40198
PDB IDs		8CQR 8SZA 8UIP	6AVZ 6AW0 6AW1 6AW3
Enriched GO Terms of Interacting Partners?		Membrane	Membrane Destabilizing Activity Cell Adhesion Cytolysis Regulation Of Innate Immune Response Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Migration Regulation Of Vascular Permeability Tissue Regeneration Regulation Of Defense Response Cell Migration Ferroptosis S100A8 Complex Regulation Of Immune Response Regulation Of Signal Transduction Regulation Of Tissue Remodeling Plasma Membrane Regulation Of Inflammatory Response Cell Motility Integrin-mediated Signaling Pathway Positive Regulation Of Defense Response Calprotectin Complex Neutrophil Aggregation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Cell Communication Negative Regulation Of Hepatocyte Proliferation Regulation Of Signaling Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Insulin Catabolic Process Leukocyte Chemotaxis Nervous System Development Regeneration Compact Myelin Peptidyl-cysteine S-nitrosylation Cellular Response To Progesterone Stimulus Cell-cell Signaling Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Homophilic Cell Adhesion Toll-like Receptor 4 Binding Connexin Binding Signaling Cellular Response To Peptide Hormone Stimulus Cell-cell Junction Regulation Of Transport Common Myeloid Progenitor Cell Proliferation Cell Junction Regulation Of Immune System Process Leukocyte Chemotaxis Involved In Inflammatory Response
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