CEND1 and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		CEND1	GLP1R
Gene Name		cell cycle exit and neuronal differentiation 1	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function		Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Adult Walking Behavior Cerebellar Granular Layer Maturation Cerebellar Purkinje Cell Differentiation Radial Glia Guided Migration Of Cerebellar Granule Cell Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS
Protein-Protein Interactions		3 interactors: EGFR GLP1R UBQLN4	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		51286	2740
HPRD ID		16300	00677
Ensembl ID		ENSG00000184524	ENSG00000112164
Uniprot IDs		Q8N111	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Second-messenger-mediated Signaling Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Learning Or Memory Cognition Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Regulation Of Protein Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Single-organism Behavior Cellular Response To Organonitrogen Compound Metal Ion Homeostasis Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Regulation Of Superoxide Anion Generation Ion Homeostasis Cellular Response To Hormone Stimulus Behavior Magnesium Ion Homeostasis Regulation Of Protein Transport Cellular Response To Estradiol Stimulus Regulation Of Establishment Of Protein Localization Protein Insertion Into Membrane Astrocyte Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic CAMP-mediated Signaling Regulation Of Catenin Import Into Nucleus Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Protein Localization Response To Epidermal Growth Factor Response To Organonitrogen Compound Cellular Response To Estrogen Stimulus Activation Of Adenylate Cyclase Activity Cellular Response To Dexamethasone Stimulus Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Cyclic-nucleotide-mediated Signaling Chemical Homeostasis Hydrogen Peroxide Metabolic Process Morphogenesis Of An Epithelial Fold Response To Dexamethasone Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of DNA Repair Tongue Development	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		1b 2a balance bm88 brdu bromo coordination cytosolic deoxyuridine destabilization dyrk1b elucidate exit incorporation lineage modulator neuro neuroblastoma neuronal partner pivotal precursors ran ranbpm retention reverted scaffolding stabilizes transiently	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		1b balance bm88 brdu bromo coordination cytosolic deoxyuridine destabilization dyrk1b elucidate exit incorporation lineage modulator neuro neuroblastoma neuronal partner pivotal precursors ran ranbpm retention reverted scaffolding stabilizes transiently	cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?		2a