SCAND1 and NFE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		SCAND1	NFE2
Description		SCAN domain containing 1	nuclear factor, erythroid 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding WW Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of DNA-templated Transcription	Nucleosome Disassembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hemostasis Positive Regulation Of DNA-templated Transcription Integrated Stress Response Signaling
Pathways			RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 25673412) Refractive error ( 32231278)	Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 22139419 24026423) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Platelet count ( 27863252 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: AGTRAP APH1A CALCOCO2 CCDC51 DGAT2L6 GOLGA6L9 GORASP2 KRT40 LHX4 MAPK3 MAPK8 MZF1 NDUFB5 NFE2 PICK1 PNMA1 POU2AF1 RER1 RNF186 RPRM SFT2D1 SHISA5 SLC17A9 TMEM207 TMEM239 TMEM95 TRIP6 TVP23A ZKSCAN3 ZKSCAN7 ZNF165 ZNF174 ZNF202 ZNF213 ZNF24 ZNF263 ZNF446 ZNF449 ZNF496 ZSCAN12 ZSCAN16 ZSCAN20 ZSCAN21 ZSCAN25 ZSCAN32	22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN UBE2I WWP1 YAP1
Entrez ID		51282	4778
HPRD ID		15298	09030
Ensembl ID		ENSG00000171222	ENSG00000123405
Uniprot IDs		P57086 Q9NZG6	A8K3E0 Q16621
PDB IDs			2KZ5
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Zinc Ion Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Metal Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Xenophagy Sequence-specific DNA Binding Regulation Of Gene Expression MAP Kinase Activity Regulation Of Macromolecule Biosynthetic Process	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Chromatin Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels Response To Radiation Response To UV Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription N-terminal Peptidyl-lysine Acetylation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxidative Stress Cellular Response To Stress DNA-binding Transcription Factor Activity Integrated Stress Response Signaling Rhythmic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Chemical Stress Positive Regulation Of Macromolecule Biosynthetic Process Response To Nutrient Levels Positive Regulation Of Biosynthetic Process Protein Monoubiquitination
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