SCAND1 and SHISA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCAND1	SHISA5
Description		SCAN domain containing 1	shisa family member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	Protein Binding	Protein Binding WW Domain Binding
	Biological Process	Positive Regulation Of DNA-templated Transcription	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 25673412) Refractive error ( 32231278)	A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		45 interacting genes: AGTRAP APH1A CALCOCO2 CCDC51 DGAT2L6 GOLGA6L9 GORASP2 KRT40 LHX4 MAPK3 MAPK8 MZF1 NDUFB5 NFE2 PICK1 PNMA1 POU2AF1 RER1 RNF186 RPRM SFT2D1 SHISA5 SLC17A9 TMEM207 TMEM239 TMEM95 TRIP6 TVP23A ZKSCAN3 ZKSCAN7 ZNF165 ZNF174 ZNF202 ZNF213 ZNF24 ZNF263 ZNF446 ZNF449 ZNF496 ZSCAN12 ZSCAN16 ZSCAN20 ZSCAN21 ZSCAN25 ZSCAN32	9 interacting genes: ARL6IP1 COPS5 DESI1 HNRNPD SCAND1 SGTA SGTB TP53 TVP23B
Entrez ID		51282	51246
HPRD ID		15298	06290
Ensembl ID		ENSG00000171222	ENSG00000164054
Uniprot IDs		P57086 Q9NZG6	Q8N114
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Zinc Ion Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Metal Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Xenophagy Sequence-specific DNA Binding Regulation Of Gene Expression MAP Kinase Activity Regulation Of Macromolecule Biosynthetic Process	TRC Complex Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization Establishment Of Protein Localization To Membrane Protein Targeting Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Regulation Of Telomere Maintenance Via Telomerase Cerebellum Development Regulation Of Telomere Maintenance Via Telomere Lengthening Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Protein Metabolic Process Cellular Localization Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Establishment Of Protein Localization To Organelle Negative Regulation Of Catabolic Process Regulation Of DNA Biosynthetic Process Circadian Regulation Of Translation Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Identical Protein Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Macrophage Migration Inhibitory Factor Binding Regulation Of Circadian Rhythm Regulation Of Telomere Maintenance Protein-folding Chaperone Binding Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Protein Modification By Small Protein Removal Histone Deacetylase Binding Circadian Rhythm BAT3 Complex Binding Localization Within Membrane Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Exosomal Secretion Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Cellular Response To Stress Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex
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