EIF3M and TRIML2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF3M	TRIML2
Description		eukaryotic translation initiation factor 3 subunit M	tripartite motif family like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytoplasm
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation	Protein Ubiquitination Response To Retinoic Acid Innate Immune Response
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Menopause (age at onset) ( 26414677) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Polycystic ovary syndrome ( 25574032)
Interacting Genes		10 interacting genes: ABI3 APP EIF3F EXOSC10 HSPB1 METTL3 SRPK1 TRIML2 ZMYND10 ZNF783	46 interacting genes: ABI2 BLOC1S2 CBY2 CCDC146 CCHCR1 CCNH CDR2 CTBP2 EIF2B1 EIF3M FAM90A1 FAM9C HGS ING5 ITGB3BP KRT15 KRT24 KRT27 KRT31 KRT34 KRT38 KRT75 MBD3L2 MBD3L3 MEOX1 MEOX2 NECAB2 NFKBID NUP62 PICK1 POLR1H POU6F2 SH2D4A STN1 SUMO2 SYCE2 TBC1D25 TCF4 TFIP11 TRIM54 TSEN54 TSG101 USHBP1 XAF1 ZBED1 ZFHX3
Entrez ID		10480	205860
HPRD ID		09969	08696
Ensembl ID		ENSG00000149100	ENSG00000179046
Uniprot IDs		Q7L2H7	A0A804HJA0 B7ZLC3 Q8N7C3
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Innate Immune Response Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Response To Other Organism Identical Protein Binding Protein Folding Chaperone Negative Regulation Of Protein Kinase C Signaling Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Positive Regulation Of Motile Cilium Assembly Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Interleukin-1 Production Regulation Of MRNA Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Axo-dendritic Transport Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Microtubule-based Movement Regulation Of Interleukin-1 Beta Production Regulation Of Translational Initiation Protein Kinase C Inhibitor Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Positive Regulation Of Cap-independent Translational Initiation Endothelial To Hematopoietic Transition MRNA M(6)A Methyltransferase Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Interleukin-1 Production Cytoplasm	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Protein Binding Supramolecular Fiber Organization Somite Specification Epithelial Cell Differentiation Cytoskeleton Morphogenesis Of An Epithelium Cytoskeleton Organization Organelle Organization Cellular Developmental Process Tissue Morphogenesis Segment Specification Somite Development Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion
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