TCEB3B and CBX5

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TCEB3B	CBX5
Gene Name		transcription elongation factor B polypeptide 3B (elongin A2)	chromobox homolog 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Integral Component Of Membrane	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex
	Molecular Function	DNA Binding	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Regulation Of DNA-templated Transcription, Elongation	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419)
Protein-Protein Interactions		16 interactors: CALCOCO2 CBX5 CDK6 CEP70 COIL DVL2 KRTAP4-12 KXD1 SOHLH2 TCEB1 TCEB2 TRAF2 TRIM37 ZBTB43 ZCCHC10 ZNF165	50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1
Entrez ID		51224	23468
HPRD ID		18169	05131
Ensembl ID		ENSG00000206181	ENSG00000094916
Uniprot IDs		Q8IYF1	P45973
PDB IDs			3FDT 3I3C
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of RNA Metabolic Process Viral Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transcription Elongation From RNA Polymerase II Promoter Cell Dedifferentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Transcription Positive Regulation Of JUN Kinase Activity Positive Regulation Of Viral Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Elongation Regulation Of JUN Kinase Activity Regulation Of Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Convergent Extension Involved In Neural Plate Elongation Histone H2A-K119 Monoubiquitination Cellular Response To Oxygen Levels Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Centriole Replication Convergent Extension Involved In Organogenesis Regulation Of Viral Process Protein Ubiquitination Regulation Of JNK Cascade Negative Regulation Of Glial Cell Apoptotic Process Protein Modification By Small Protein Conjugation RNA Metabolic Process Regulation Of Stress-activated MAPK Cascade Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Negative Regulation Of Cellular Senescence Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of MAP Kinase Activity Cellular Response To Nitric Oxide Gene Expression Regulation Of Centriole Replication	Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification
Tagcloud ?			1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Difference) ?			1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Intersection) ?