ELOA2 and CBX5

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ELOA2	CBX5
Description		elongin A2	chromobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Elongin Complex	Histone Deacetylase Complex Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Histone H3K9me2/3 Reader Activity DNA-binding Transcription Factor Binding Histone Reader Activity
	Biological Process	Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs			Copper
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: CALCOCO2 CBX5 CDK6 CEP70 CHD2 COIL DVL2 ELOB ELOC HSF2BP KRTAP4-12 KXD1 NKAPD1 RNPS1 SOHLH2 SREK1IP1 TRAF2 TRIM37 ZBTB43 ZCCHC10 ZNF138 ZNF165 ZNF23	61 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AC25 H2BC26 H3-4 H3C1 H3C15 H4C16 HDAC4 HDAC5 HDAC9 HECW2 INCENP ISG15 LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBC UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		51224	23468
HPRD ID		18169	05131
Ensembl ID		ENSG00000206181	ENSG00000094916
Uniprot IDs		Q8IYF1	P45973 V9HWG0
PDB IDs			3FDT 3I3C 8UXQ
Enriched GO Terms of Interacting Partners?		Target-directed MiRNA Degradation Elongin Complex Protein-macromolecule Adaptor Activity Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Hematopoietic Stem Cell Differentiation Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Tumor Necrosis Factor Receptor Binding Aggresome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin D2-CDK6 Complex TORC2 Complex Disassembly RNA Polymerase III General Transcription Initiation Factor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Initiation At RNA Polymerase II Promoter Transcription Corepressor Binding RNA Catabolic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding	Chromatin Organization Chromatin Remodeling Chromosome Nucleus Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Epigenetic Regulation Of Gene Expression Heterochromatin Formation Chromo Shadow Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Heterochromatin DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein-DNA Complex Assembly Chromosome Segregation Regulation Of Macromolecule Biosynthetic Process Euchromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Assembly Chromatin MIS12/MIND Type Complex Chromosome Organization Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region DNA Damage Response Histone Deacetylase Activity, Hydrolytic Mechanism Transcription Corepressor Activity Histone H2AK127 Ubiquitin Ligase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?