ELOA2 and CHD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ELOA2	CHD2
Description		elongin A2	chromodomain helicase DNA binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Elongin Complex	Chromatin Nucleus
	Molecular Function	Protein Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation	Chromatin Organization Chromatin Remodeling DNA Damage Response Muscle Organ Development Gene Expression Nucleosome Organization Hematopoietic Stem Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Adolescent idiopathic scoliosis ( 30395268) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Daytime nap ( 33568662) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30224653)
Interacting Genes		23 interacting genes: CALCOCO2 CBX5 CDK6 CEP70 CHD2 COIL DVL2 ELOB ELOC HSF2BP KRTAP4-12 KXD1 NKAPD1 RNPS1 SOHLH2 SREK1IP1 TRAF2 TRIM37 ZBTB43 ZCCHC10 ZNF138 ZNF165 ZNF23	11 interacting genes: BEND7 ELOA2 MEOX2 MID2 SRPK2 TEKT1 THAP1 TRIM41 TRIM54 TULP3 ZNF398
Entrez ID		51224	1106
HPRD ID		18169	03669
Ensembl ID		ENSG00000206181	ENSG00000173575
Uniprot IDs		Q8IYF1	O14647
PDB IDs
Enriched GO Terms of Interacting Partners?		Target-directed MiRNA Degradation Elongin Complex Protein-macromolecule Adaptor Activity Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Hematopoietic Stem Cell Differentiation Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Tumor Necrosis Factor Receptor Binding Aggresome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin D2-CDK6 Complex TORC2 Complex Disassembly RNA Polymerase III General Transcription Initiation Factor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Initiation At RNA Polymerase II Promoter Transcription Corepressor Binding RNA Catabolic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding	Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Tissue Development Negative Regulation Of Endothelial Cell Migration Limb Development Regulation Of RNA Metabolic Process Innate Immune Response Defense Response To Other Organism Negative Regulation Of Viral Process Defense Response To Symbiont Zinc Ion Binding Radial Pattern Formation Bronchus Morphogenesis Microtubule Ubiquitin Protein Ligase Activity
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