TRIM41 and DEPTOR

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		TRIM41	DEPTOR
Description		tripartite motif containing 41	DEP domain containing MTOR interacting protein
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol	Lysosome Lysosomal Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Lipid Binding Protein Serine/threonine Kinase Inhibitor Activity Phosphatidic Acid Binding
	Biological Process	Protein Monoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide	Autophagosome Assembly Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Cell Size Negative Regulation Of TORC2 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Choroid plexus volume ( 31530798) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Idiopathic pulmonary fibrosis ( 31710517) Platelet count ( 32888494) Plateletcrit ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		144 interacting genes: AEN AKTIP ANKRD23 AP1M1 APP AQP1 BIVM BRAP BYSL C8orf33 CARD10 CCNL2 CEP44 CHD2 CSNK2A1 CSNK2A2 DDX41 DEPTOR DRC4 DVL3 EHHADH EZHIP FAM124A FAM161A FAM9A FLACC1 FRA10AC1 GPATCH2L IKBKG JRK KATNBL1 KIFC3 KRTAP10-8 KRTAP10-9 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MID2 MOBP MORF4L1 MORF4L2 MPP3 NCK2 NEDD4L NFE2L2 NOD2 PBX4 PHC2 PHF11 PHF7 PLAGL2 PRDM14 PRKCA PRKCB PRPF31 PTPN3 PUS7L RBAK RNPS1 SORBS3 SRPK2 STX11 SUV39H1 SYCE1 SYTL4 TBC1D26 TCEA2 TCEANC TLE5 TNNI1 TOP3B TP53 TRAIP TRIM17 TRIM26 TRIM4 TRIM52 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2I ZBTB24 ZBTB26 ZBTB38 ZBTB39 ZBTB48 ZBTB8A ZCCHC7 ZFP1 ZFP2 ZFP64 ZMAT5 ZNF121 ZNF134 ZNF138 ZNF165 ZNF2 ZNF219 ZNF24 ZNF250 ZNF251 ZNF26 ZNF263 ZNF264 ZNF266 ZNF275 ZNF286A ZNF319 ZNF329 ZNF343 ZNF398 ZNF408 ZNF417 ZNF439 ZNF460 ZNF473 ZNF48 ZNF490 ZNF497 ZNF526 ZNF552 ZNF564 ZNF575 ZNF587 ZNF629 ZNF648 ZNF653 ZNF655 ZNF670 ZNF691 ZNF696 ZNF71 ZNF773 ZNF780A ZNF784 ZNF792 ZNF835 ZNF837 ZSCAN16 ZSCAN21 ZSCAN26	13 interacting genes: ANKRD11 APP CCDC110 CHKA CUL5 FBXO25 LNX1 MAPK3 PSME3 RPS6KA1 RPS6KB1 TRAF1 TRIM41
Entrez ID		90933	64798
HPRD ID		15558	13137
Ensembl ID		ENSG00000146063	ENSG00000155792
Uniprot IDs		Q8WV44	Q8TB45
PDB IDs		2EGM	7DKL 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7PED
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Negative Regulation Of DNA-templated Transcription Histone H3T6 Kinase Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Kinase CK2 Complex Protein Ubiquitination Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein Kinase C Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Stem Cell Differentiation Somite Specification	Regulation Of Extrinsic Apoptotic Signaling Pathway TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Cytosol Identical Protein Binding Protein Modification Process Face Development ERBB2 Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of TOR Signaling Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Signal Transduction Positive Regulation Of Defense Response Apoptotic Process Protein Metabolic Process Programmed Cell Death Negative Regulation Of Signaling Cell Death Negative Regulation Of Cell Communication Regulation Of Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Choline Kinase Activity Kinase Activity Cellular Response To Nutrient Levels SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Ubiquitination Transferase Activity SCF Ubiquitin Ligase Complex Glial Cell Development Negative Regulation Of TORC1 Signaling Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cell Communication Positive Regulation Of Protein Import Regulation Of Signaling ERBB Signaling Pathway Protein Modification By Small Protein Conjugation Symbiont-mediated Suppression Of Host Innate Immune Response PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Growth Factor Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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