LRP10 and SLC14A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRP10	SLC14A2
Description		LDL receptor related protein 10	solute carrier family 14 member 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Clathrin-coated Pit Membrane	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Protein Binding	Protein Binding Urea Transmembrane Transporter Activity Cell Adhesion Molecule Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Endocytosis Vesicle-mediated Transport Inner Ear Development	Urea Transport Transmembrane Transport Urea Transmembrane Transport
Pathways		Retinoid metabolism and transport	SLC-mediated transport of organic cations
Drugs
Diseases
GWAS		Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Neutrophil count ( 32888494)	Biochemical measures ( 19260141) Bladder cancer ( 24163127) Blood urea nitrogen levels ( 31152163 29403010) Cerebrospinal fluid clusterin levels ( 26545630) Cocaine dependence ( 31212010) FEV1 ( 30804560) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Intake of total sugars ( 31005972) Lateral orbital frontal cortex volume ( 31530798) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Male-pattern baldness ( 28196072 27182965) Menarche (age at onset) ( 21102462) Metabolite levels ( 23823483 21909109) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581) Pulse pressure ( 27841878 28135244) Red blood cell count ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 27841878) Takayasu arteritis ( 33308445) Urate levels ( 31578528)
Interacting Genes		23 interacting genes: C16orf92 CISD2 EBP FAM209A GGA3 GJB5 GOLM2 GORAB HTRA1 LMNA MGST3 MRPS18B NOTO PDCD1LG2 PLEKHO1 SLC10A1 SLC14A2 SLC71A2 SMIM1 ST6GALNAC6 TMEM179B TMEM237 TMEM243	12 interacting genes: ARLN CMTM7 EHHADH LAT LRP10 PLN PLP2 SEC22A TMEM97 TNF TRARG1 VAMP5
Entrez ID		26020	8170
HPRD ID		14311	03366
Ensembl ID		ENSG00000197324	ENSG00000132874
Uniprot IDs		Q7Z4F1	Q15849
PDB IDs			8BLO 8XD7 8XD9 8XDA 8XDB 8XDC 8XDD 8XDE
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Heart Rate Negative Regulation Of Blood Circulation Negative Regulation Of Heart Contraction Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Calcium-mediated Signaling Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Membrane Negative Regulation Of Bile Acid Secretion Protein Localization To Cell Periphery Localization Within Membrane Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Chronic Inflammatory Response To Antigenic Stimulus Protein Localization To Plasma Membrane Response To Gram-negative Bacterium Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Protein Localization To Membrane Positive Regulation Of Vitamin D Biosynthetic Process Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport TCR Signalosome B-1a B Cell Differentiation
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